2. Autophagy
  3. Atg7 Autophagy
  4. Antitumor agent-82

Antitumor agent-82 (compound 6g) 是一种有效的抗肿瘤剂。Antitumor agent-82 显示出抗增殖活性。Antitumor agent-82 通过 ATG5/ATG7信号通路诱导细胞自噬 (Autophagy)。

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Antitumor agent-82

Antitumor agent-82 Chemical Structure

CAS No. : 3037605-45-8

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Antitumor agent-82 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-82 (compound 6g) is a potent anti-tumor agent. Antitumor agent-82 shows anti-proliferative activity. Antitumor agent-82 induces cell Autophagy by the ATG5/ATG7 signaling pathway[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
786-0 IC50
2.71 μM
Compound: 6g
Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human 786-0 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36459757]
A-375 IC50
11.5 μM
Compound: 6g
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36459757]
BGC-823 IC50
24.8 μM
Compound: 6g
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36459757]
CWR22R IC50
3.86 μM
Compound: 6g
Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36459757]
HCT-116 IC50
4.57 μM
Compound: 6g
Antiproliferative activity against human HCT-116 cells expressing ATG5-FLAG assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells expressing ATG5-FLAG assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
[PMID: 36459757]
HCT-116 IC50
4.71 μM
Compound: 6g
Antiproliferative activity against p53 knockout human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
Antiproliferative activity against p53 knockout human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
[PMID: 36459757]
HCT-116 IC50
4.97 μM
Compound: 6g
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
[PMID: 36459757]
HCT-116 IC50
5.09 μM
Compound: 6g
Antiproliferative activity against human HCT-116 cells expressing ATG7-FLAG assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
Antiproliferative activity against human HCT-116 cells expressing ATG7-FLAG assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
[PMID: 36459757]
HCT-116 IC50
7.36 μM
Compound: 6g
Antiproliferative activity against ATG5 knockout human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
Antiproliferative activity against ATG5 knockout human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
[PMID: 36459757]
HCT-116 IC50
7.89 μM
Compound: 6g
Antiproliferative activity against ATG7 knockout human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
Antiproliferative activity against ATG7 knockout human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by CCK-8 assay
[PMID: 36459757]
HT-29 IC50
2.02 μM
Compound: 6g
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36459757]
KB IC50
8.12 μM
Compound: 6g
Antiproliferative activity against human KB cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human KB cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36459757]
MCF7 IC50
13.5 μM
Compound: 6g
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36459757]
SK-OV-3 IC50
10.6 μM
Compound: 6g
Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human SK-OV-3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
[PMID: 36459757]
体外研究
(In Vitro)

Antitumor agent-82 (compound 6g) (0-100 μM; 48 h) shows anti-proliferative activity with IC50s of 24.8, 13.5, 11.5, 2.71, 2.02, 4.53 μM for BGC-823, MCF7, A375, 786-O, HT-29, Blu-87 cells, respectively[1].
Antitumor agent-82 (0-4 μM; 0-7 days) inhibits cell growth in a dose and time-dependent manner against HCT116 cells[1].
Antitumor agent-82 (0-5 μM; 0-60 h) activates autophagy by the ATG5/ATG7 signaling pathway in HCT116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-82 相关抗体:

Cell Proliferation Assay[1]

Cell Line: BGC-823, MCF7, A375, 786-O, HT-29, Blu-87 cells
Concentration: 0-100 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 24.8, 13.5, 11.5, 2.71, 2.02, 4.53 µM for BGC-823, MCF7, A375, 786-O, HT-29, Blu-87 cells, respectively.

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 0-5 µM
Incubation Time: 0-60 h
Result: Induced autophagy with no influences on the expression of caspase-3, cleaved caspase-3 and p53 protein, significantly increased the expression of LC3-II and p62.
体内研究
(In Vivo)

Antitumor agent-82 (45 mg/kg; i.p.; every two days for 16 days) shows anti-cancer activity for mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male BALB/c mice[1]
Dosage: 45 mg/kg
Administration: I.p.; every two days for 16 days
Result: Reduced tumor volume and resulted in a considerable reduction of the tumor weight of 69.69%.
分子量

510.72

Formula

C32H42N6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-82 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-823037605-45-8Antitumor agent82Antitumor agent 82Atg7Autophagyanti-tumoranti-proliferativeautophagyHCT116ATG5/ATG7Inhibitorinhibitorinhibit

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