2. Autophagy
  3. Atg7 Autophagy
  4. Antitumor agent-82

Antitumor agent-82 (compound 6g) 是一种有效的抗肿瘤剂。Antitumor agent-82 显示出抗增殖活性。Antitumor agent-82 通过 ATG5/ATG7信号通路诱导细胞自噬 (Autophagy)。

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Antitumor agent-82

Antitumor agent-82 Chemical Structure

CAS No. : 3037605-45-8

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Antitumor agent-82 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-82 (compound 6g) is a potent anti-tumor agent. Antitumor agent-82 shows anti-proliferative activity. Antitumor agent-82 induces cell Autophagy by the ATG5/ATG7 signaling pathway[1].

体外研究
(In Vitro)

Antitumor agent-82 (compound 6g) (0-100 μM; 48 h) shows anti-proliferative activity with IC50s of 24.8, 13.5, 11.5, 2.71, 2.02, 4.53 μM for BGC-823, MCF7, A375, 786-O, HT-29, Blu-87 cells, respectively[1].
Antitumor agent-82 (0-4 μM; 0-7 days) inhibits cell growth in a dose and time-dependent manner against HCT116 cells[1].
Antitumor agent-82 (0-5 μM; 0-60 h) activates autophagy by the ATG5/ATG7 signaling pathway in HCT116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-82 相关抗体:

Cell Proliferation Assay[1]

Cell Line: BGC-823, MCF7, A375, 786-O, HT-29, Blu-87 cells
Concentration: 0-100 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 24.8, 13.5, 11.5, 2.71, 2.02, 4.53 µM for BGC-823, MCF7, A375, 786-O, HT-29, Blu-87 cells, respectively.

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 0-5 µM
Incubation Time: 0-60 h
Result: Induced autophagy with no influences on the expression of caspase-3, cleaved caspase-3 and p53 protein, significantly increased the expression of LC3-II and p62.
体内研究
(In Vivo)

Antitumor agent-82 (45 mg/kg; i.p.; every two days for 16 days) shows anti-cancer activity for mouse[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male BALB/c mice[1]
Dosage: 45 mg/kg
Administration: I.p.; every two days for 16 days
Result: Reduced tumor volume and resulted in a considerable reduction of the tumor weight of 69.69%.
分子量

510.72

Formula

C32H42N6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-82 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-823037605-45-8Antitumor agent82Antitumor agent 82Atg7Autophagyanti-tumoranti-proliferativeautophagyHCT116ATG5/ATG7Inhibitorinhibitorinhibit

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