2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Reactive Oxygen Species (ROS) Photosensitizer
  4. Antitumor photosensitizer-9

Antitumor photosensitizer-9 是一种近红外光敏剂 (Photosensitizer)，具有高单线态产氧率 (相对速率 = 1.79)。Antitumor photosensitizer-9 对多种癌细胞表现出极强光毒性，光照下可诱导 ROS 生成。Antitumor photosensitizer-9 在体内抑制肿瘤生长，在低药物和光剂量下表现出优异的抗癌光动力疗法 (PDT) 效果。Antitumor photosensitizer-9 可用于光动力疗法研究。

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Antitumor photosensitizer-9

Antitumor photosensitizer-9 Chemical Structure

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Antitumor photosensitizer-9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor photosensitizer-9 is a near-infrared Photosensitizer (PS) with a high singlet oxygen production rate (relative rate = 1.79). Antitumor photosensitizer-9 exhibits strong phototoxicity against various cancer cells and induces ROS generation under light irradiation. Antitumor photosensitizer-9 inhibits tumor growth in vivo and exhibits excellent anticancer photodynamic therapy (PDT) efficacy at low drug and light doses. Antitumor photosensitizer-9 can be used in photodynamic therapy research[1].

体外研究
(In Vitro)

Antitumor photosensitizer-9 (Compound A1) (2 小时) 对 HeLa 细胞表现出光剂量相关性光毒性，IC50 < 5.0 nM[1]。
Antitumor photosensitizer-9 (2 小时) 在 HeLa、HepG 2、B16-F10 和 HUVEC 细胞中，表现出光毒性 (IC50s = 3.7、3.6、4.5、3.7 nM) 和暗细胞毒性 (IC50 = 11.5、13.5、12.7、10.7 μM)[1]。
Antitumor photosensitizer-9 (5 μM，2 小时) 在 HeLa 细胞中达到细胞内积累峰值，主要在内质网中积累[1]。
Antitumor photosensitizer-9 (0-500 nM，2 小时) 在光照下诱导 HeLa 细胞中 ROS 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor photosensitizer-9 相关抗体:
体内研究
(In Vivo)

Antitumor photosensitizer-9 (Compound A1) (2 mg/kg，静脉注射，一次) 在携带 HeLa 细胞的裸鼠中可抑制肿瘤生长，且无生理毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c Nude mice (6-8 weeks old, 20-22 g) bearing HeLa cells (5 × 106 cells, 0.1 mL, s.c.) [1]
Dosage: 2 mg/kg
Administration: i.v., once, 24 days of PDT treatment
Result: Inhibited tumor growth, with tumor volume decreased by 78% and had no physiological toxicity, was more effective than photosensitizers Ce6 (HY-13594) and BDP4 (HY-D1452).
分子量

809.54

Formula

C44H41BIN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor photosensitizer-9 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor photosensitizer-9Antitumor photosensitizer9Antitumor photosensitizer 9Reactive Oxygen Species (ROS)PhotosensitizerHeLa cellsNude miceInhibitorinhibitorinhibit

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