2. Apoptosis
  3. Apoptosis
  4. Apoptosis inducer 9

Apoptosis inducer 9 诱导细胞凋亡，IC50 值为 4.21 μM。Apoptosis inducer 9 通过线粒体途径诱导细胞凋亡，增强 Cl-caspase-3, Cl-caspase-9 和 Cl-PARP 的表达。Apoptosis inducer 9 可开发成新的抗增殖活性分子。

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Apoptosis inducer 9 Chemical Structure

Apoptosis inducer 9 Chemical Structure

CAS No. : 2551067-10-6

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Apoptosis inducer 9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 9 induces apoptosis with IC50 value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents[1].

体外研究
(In Vitro)

Apoptosis inducer 9 (Compound A1) (5-10 μM, 12 hours) induces apoptosis in HepG-2 cells in a concentration-dependent manner[1].
Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) triggers Cl-caspase-3, Cl-caspase-9 and Cl-PARP protein expression in HepG-2, thereby inducing apoptosis[1].
Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) induces apoptosis by triggering the mitochondrial apoptosis pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 9 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG-2 cells
Concentration: 5 and 10 μM
Incubation Time: 12 hours
Result: Apoptotic bodies appeared shrunken, nuclei shrunken and cells fragmented. The apoptosis rates at concentrations of 5 μM and 10 μM were 10.2% and 42.7%, respectively.

Western Blot Analysis[1]

Cell Line: HepG-2 cells
Concentration: 0, 5, 10 and 20 μM
Incubation Time: 24 hours
Result: Triggered the caspase cascade in HepG-2 and the corresponding protein expression gradually increased.

Western Blot Analysis[1]

Cell Line: HepG-2 cells
Concentration: 0, 5, 10 and 20 μM
Incubation Time: 24 hours
Result: Induced up-regulation of the expression of Bcl-2, Bax and p53 proteins, and increased the ratio of Bax/Bcl-2.
分子量

601.88

Formula

C34H55N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 9 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Apoptosis inducer 92551067-10-6Apoptosis inducer9Apoptosis inducer-9Apoptosisanti-proliferative activitymitochondrial pathwayInhibitorinhibitorinhibit

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