2. Others NF-κB Membrane Transporter/Ion Channel Immunology/Inflammation
  3. NF-κB Sodium Channel NOD-like Receptor (NLR) Reference Standards
  4. Articaine hydrochloride (Standard)

Articaine hydrochloride (Standard)  (Synonyms: 盐酸阿替卡因 (标准品); Hoe-045 (Standard))

目录号: HY-B0516R 纯度: ≥98%
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Articaine (Hoe-045) hydrochloride (Standard) 是 Articaine hydrochloride (HY-B0516) 的分析标准品。本产品用于研究及分析应用。Articaine (Hoe-045) hydrochloride 是一种电压门控钠离子通道 (如 rNav1.4、hNav1.7、rNav1.8) 的选择性抑制剂，对开放态 Na+ 通道的 IC50 为 15.8 μM；而对失活态和静息态 Na+ 通道的 IC50 分别为 40.6 μM 和 378 μM。Articaine hydrochloride 通过抑制 Na+ 内流阻断神经冲动传导，发挥局部麻醉活性，同时可抑制 NF-κB 激活及 NLRP3 炎症小体通路，展现抗炎功能。Articaine hydrochloride 可用于牙科局部麻醉、炎症相关疾病 (如急性肾损伤) 的研究。

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Articaine hydrochloride (Standard) Chemical Structure

Articaine hydrochloride (Standard) Chemical Structure

CAS No. : 23964-57-0

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规格 价格 是否有货 数量
5 mg ￥315
3 - 5 周
10 mg ￥472
3 - 5 周
25 mg ￥850
3 - 5 周
50 mg ￥1275
3 - 5 周
100 mg ￥1913
3 - 5 周
200 mg   询价  
500 mg   询价  

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生物活性

Articaine (Hoe-045) hydrochloride (Standard) is the analytical standard of Articaine hydrochloride (HY-B0516). This product is intended for research and analytical applications. Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 μM for open-state Na+ channels, and IC50 of 40.6 μM and 378 μM for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury).

分子量

320.84

同用名

盐酸阿替卡因 (标准品); Hoe-045 (Standard)

Formula

C13H21ClN2O3S
CAS 号
中文名称

盐酸阿替卡因 (标准品)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Articaine hydrochloride (Standard) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Articaine hydrochloride (Standard)23964-57-0Hoe-045 (Standard)盐酸阿替卡因 (标准品)NF-κBSodium ChannelNOD-like Receptor (NLR)Reference StandardsNuclear factor-κBNuclear factor-kappaBNa channelsNa+ channelsInhibitorinhibitorinhibit

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