2. Apoptosis
  3. Apoptosis
  4. Azathioprine sodium

Azathioprine sodium  (Synonyms: 硫唑嘌呤钠盐; BW 57-322 sodium)

目录号: HY-B0256A
产品使用指南

摩尔计算器

Azathioprine (BW 57-322) sodium 是一种具有口服活性的免疫抑制剂 (immunosuppressive agent)。硫唑嘌呤在体内可以转化为活性代谢物 6-巯基嘌呤( 6-MP )，具有骨髓抑制作用，可诱导细胞凋亡 (apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Azathioprine sodium Chemical Structure

Azathioprine sodium Chemical Structure

CAS No. : 55774-33-9

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Azathioprine sodium 的其他形式现货产品:

Customer Review

Other Forms of Azathioprine sodium:

Azathioprine sodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Azathioprine (BW 57-322) sodium is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis[1][3].

体外研究
(In Vitro)

Azathioprine (0-50 μM, 48 hours) sodium can induce severe intracellular GSH depletion with relevant concentrations in both primary rat and human hepatocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Azathioprine sodium 相关抗体:

Cell Viability Assay[2]

Cell Line: Rat hepatocytes, Human hepatocytes
Concentration: 0-50 μM
Incubation Time: 24-48 hours
Result: Showed the decrease in cell viability and intracellular GSH levels in rat hepatocytes as low concentration of 0.5 μM but no significant decrease in cell viability at concentrations below 50 μM as well as GSH depletion was obviously noted at a concentration as low as 1 μM in human hepatocytes.
体内研究
(In Vivo)

Azathioprine (oral gavage, 25-400 mg/kg, everyday, 10days) sodium can affect bone marrow cells, red blood cells, and peripheral blood cytokines and other related parameters in a dose-dependent manner, and can induce apoptosis in female CD-1 mice and ICR mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Outbred female CD-1 mice, Female ICR mice[3]
Dosage: 25-400 mg/kg
Administration: Oral gavage; everyday; 10days
Result: Induced a decrease in erythrocyte-related parameters as well as leukocyte-related parameters in a dose-dependent manner.
Induced 52.4%, 35.4%, 17.9%, 16.1% and 15.2% reduction in bone marrow cells at concentrations of 40, 60, 80, 100 and 120 mg/kg, respectively while fms-like tyrosine kinase-3(FLT-3) ligand (FL)-related cytokines were increased.
Increased induction of apoptosis.
Clinical Trial
分子量

300.25

Formula

C9H7N7NaO2S
CAS 号
中文名称

依木兰钠盐；咪唑硫嘌呤钠盐；硫唑嘌呤钠盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Azathioprine sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azathioprine55774-33-9BW 57-322依木兰钠盐咪唑硫嘌呤钠盐硫唑嘌呤钠盐ApoptosisAutoimmunity inhibitor6-MercaptopurineRheumatic diseasesInfectious skin diseasesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Azathioprine sodium
目录号：
HY-B0256A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z