2. Neuronal Signaling NF-κB
  3. Amyloid-β Keap1-Nrf2
  4. Aβ-IN-6

Aβ-IN-6 减少小胶质细胞释放的促炎细胞因子。Aβ-IN-6 显着诱导 Nrf2 核转位，阻碍 Aβ 寡聚体形成。Aβ-IN-6 通过调节体内氧化应激模型中的氧化还原敏感信号通路发挥一致的神经保护作用。Aβ-IN-6 具有口服活性，并且显示抗炎、抗氧化和抗寡聚活性。Aβ-IN-6 具有用于阿尔茨海默病 (AD) 研究的潜力。

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Aβ-IN-6 Chemical Structure

Aβ-IN-6 Chemical Structure

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Aβ-IN-6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research[1].

体外研究
(In Vitro)

Aβ-IN-6 (化合物 4; 1-20 μM; 24 小时) 从 5 μM 的浓度开始显着降低小胶质细胞的活力[1]。
Aβ-IN-6 (1.25-40 μM; 24 小时) 在 SH-SY5Y 神经母细胞瘤细胞中浓度高于 2.5 μM 时有显着的细胞毒性[1]。
Aβ-IN-6 (2.5 μM; 3小时) 显着诱导 Nrf2 核转位[1]。
Aβ-IN-6 (2.5 μM) 显着抑制 LPS 诱导的两种细胞因子和 NLRP3 mRNA 水平的升高[1]。
Aβ-IN-6 (1, 2.5 μM; 预处理 1 小时然后用 LPS 刺激 24 小时) 显着降低 LPS 诱导的 TNF-α 和 IL-1β 的释放[1]。
Aβ-IN-6 (2.5 μM; 24 小时) 在叔丁基氢过氧化物 (t-BuOOH; 50 μM 30 分钟) 之前预处理，可以减少 ROS 形成，抑制率约为 18%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aβ-IN-6 相关抗体:

Cell Viability Assay[1]

Cell Line: Microglia
Concentration: 1-20 μM
Incubation Time: 24 h
Result: Markedly reduced microglia viability starting from the concentration of 5 μM.

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time: 24 h
Result: Recorded significant cytotoxicity at concentrations higher than 2.5 μM.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 2.5 μM 3 h Significantly induced Nrf2 nuclear translocation. SH-SY5Y cells 2.5 μM
Incubation Time: 3 h
Result: Significantly induced Nrf2 nuclear translocation.

RT-PCR[1]

Cell Line: Microglia
Concentration: 2.5 μM
Incubation Time: Pretreated for 1 h and then stimulated with 100 ng/mL LPS for 6 h
Result: Markedly suppressed the LPS-induced increase of mRNA levels of the two cytokines and NLRP3, confirming the anti-inflammatory properties.
体内研究
(In Vivo)

Aβ-IN-6 (化合物 4; 10 μM; 添加到标准食物中) 有效地将神经退行性疾病 (D-spastin 功能丧失模型)下幼虫肌肉和大脑中增加的 ROS 水平恢复到在 Spastin 果蝇模型中观察到的对照水平[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spastin Drosophila model[1]
Dosage: 10 μM
Administration: Added to standard food (dissolved in DMSO)
Result: Efficiently restored the increased ROS level in larval muscles and brains under neurodegenerative conditions (D-spastin loss of function model) to that observed for the control.
Significantly ameliorated the phenotype associated with spastin reduction.
分子量

473.56

Formula

C28H31N3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aβ-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ-IN-6Amyloid-βKeap1-Nrf2β-amyloid peptideAβAbetapro-inflammatorymicroglia cellsNrf2nuclear translocationAβ oligomerneuroprotectiveredox-sensitiveoxidative stressantiinflammatoryAntioxidantAnti-oligomericAlzheimer's diseaseADInhibitorinhibitorinhibit

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