2. Anti-infection
  3. Influenza Virus
  4. BCX-1898

BCX-1898 是一种环戊烷衍生物，是口服有效的，选择性的流感病毒神经氨酸酶 (influenza virus neuraminidase) 抑制剂。BCX-1898 具有抗病毒活性，对 MDCK 细胞中的甲型流感病毒 (H1N1、H3N2、H5N1) 和乙型流感病毒复制的 EC50 值为 <0.01-21 μM。BCX-1898 显示出对小鼠流感模型的保护作用。

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BCX-1898 Chemical Structure

BCX-1898 Chemical Structure

CAS No. : 345267-14-3

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BCX-1898 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BCX-1898, a cyclopentane derivative, is an orally active and selective influenza virus neuraminidase inhibitor. BCX-1898 has antiviral activity with EC50s of <0.01-21 μM on influenza A (H1N1, H3N2, and H5N1) and influenza B viruses replication in MDCK cells. BCX-1898 shows protection against the mouse influenza model[1][2].

体内研究
(In Vivo)

BCX-1898 (1, 10 mg/kg/天; 口服给药; 22 天) 以 10 mg/kg/天显示出对流感病毒的完全保护[2]。
BCX-1898 (0.01, 0.1 mg/kg/天; 鼻内给药; 20 天) 表现出完全保护作用 (10 个模型中有 10 存活)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (13-18 g) infected with the A/Turkey/Mas/ 76 X A/Beijing/32/92 (H6N2) influenza virus[2]
Dosage: 1, 10 mg/kg/day
Administration: Oral; 22 days
Result: Showed complete protection against the influenza virus with 10 mg/kg/day, whereas at dose level (1 mg/kg/day) showed only a 10% protection against the influenza virus.
分子量

340.46

Formula

C17H32N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BCX-1898 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCX-1898345267-14-3BCX1898BCX 1898Influenza VirusCyclopentaneinfluenza virusneuraminidaseH1N1H3N2H5N1MDCK cellsInhibitorinhibitorinhibit

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目录号：
HY-105395
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