BFMO  (Synonyms: N,N'-Difurfuryloxamide; N1,N2-Bis(furan-2-ylmethyl)oxalamide)

BFMO is a bidentate ligand for copper (Cu) catalysts that can effectively promote copper-catalyzed N-arylation coupling reactions of (hetero)aryl bromides with aniline, cyclic secondary amines, and acyclic secondary amines. BFMO coordinates with copper ions to form stable catalytically active species, which reduces the activation energy of the reaction and improves the reactivity of the substrate. It exhibits excellent selectivity for coupling of acyclic secondary amines with large steric hindrance, and can achieve direct monoarylation of piperazine with (hetero)aryl bromides to generate important pharmaceutical structural units^[1][2].

248.24

C₁₂H₁₂N₂O₄

69010-90-8

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

• [1]. Bhunia S, et al. N,N'-Bisoxalamides Enhance the Catalytic Activity in Cu-Catalyzed Coupling of (Hetero)Aryl Bromides with Anilines and Secondary Amines. J Org Chem. 2017 Dec 1;82(23):12603-12612.  [Content Brief]

  [2]. Hu F, et al. Roles of naturally occurring biogenic iron-manganese oxides (BFMO) in PMS-based environmental remediation: A complete electron transfer pathway. J Environ Sci (China). 2025 Sep;155:795-805.  [Content Brief]