Biliverdin dihydrochloride  (Synonyms: 胆绿素盐酸盐)

Biliverdin dihydrochloride, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin dihydrochloride and carbon monoxide and iron by heme oxidase. Biliverdin dihydrochloride is then quickly broken down to bilirubin by Biliverdin hydrochloride reductase. Biliverdin hydrochloride is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant^[1].

Biliverdin dihydrochloride 被认为是血红素降解的废物。当红细胞因溶血性疾病或自然凋亡而溶解时，血红素就会被释放。血红素在血红素加氧酶中利用三个氧分子和七个电子进行代谢，产生 Biliverdin IX-α、一氧化碳和亚铁。Biliverdin IX-α 通过 NADPH 依赖性胆绿素还原酶代谢为胆红素 IX-α^[1]。
研究表明，Biliverdin dihydrochloride 的积累会上调胆绿素还原酶的活性，Biliverdin 还原酶是一种调节先天免疫系统的酶^[1]。
Biliverdin dihydrochloride下调血管平滑肌细胞的增殖，并在受损血管中表现出抗氧化作用。这减少了血管内膜的形成，并阻止了新血管形成和血管生成^[1]。
Biliverdin dihydrochloride 通过下调促炎性细胞因子（如 TLR-4）和刺激抗炎细胞因子（如 IL-10）的产生来减轻炎症^[1]。
Biliverdin dihydrochloride 是一种羟基过氧化物基团的清除剂，具有 Biliverdin dihydrochloride 的抗氧化作用^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Biliverdin dihydrochloride 显著减少大鼠球囊血管成形术和血管移植术后的内膜增生^[1]。
anti-mutagenic, antioxidant, anti-inflammatory, and immunosuppressant, tetrapyrrolic pigment

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

655.57

C₃₃H₃₆Cl₂N₄O₆

55482-27-4

胆绿素盐酸盐

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. McDonnell MC, et al. Biochemistry, Biliverdin. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.  [Content Brief]