1. Autophagy
  2. Autophagy
  3. BRD5631

BRD5631 是一种自噬 (autophagy) 增强剂,通过与 mTOR 无关的通路来增强自噬。BRD5631 能够影响先前与自噬相关的几种细胞疾病表型,包括蛋白聚集、细胞存活、细菌复制和炎性因子的产生。

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BRD5631 Chemical Structure

BRD5631 Chemical Structure

CAS No. : 2446154-91-0

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Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

IF

    BRD5631 purchased from MCE. Usage Cited in: Cancer Gene Ther. 2022 Dec 9.  [Abstract]

    Both HLY78 and BRD5631 significantly abrogate the effect of miR-219-5p on SKOV3 and SKOV3/DDP cell apoptosis.

    BRD5631 purchased from MCE. Usage Cited in: Cancer Gene Ther. 2022 Dec 9.  [Abstract]

    Both HLY78 and BRD5631 significantly abrogate the effects of miR-219-5p on SKOV3 and SKOV3/DDP cell invasion (fig E) and migration (fig F).
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production[1].

    IC50 & Target

    Autophagy[1]

    体外研究
    (In Vitro)

    BRD5631 (10 μM, 48 hours) leads to increased levels of LC3-II in HeLa cells. BRD5631 stimulates formation of new autophagosomes, which is consistent with its ability to increase numbers of autolysosomes in the mCherry-GFP-LC3 assay[1].
    BRD5631 does not enhance autophagy by directly inhibiting mTOR or the mTOR signaling pathway. BRD5631 suppressed IL-1β secretion in an autophagy-dependent manner[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: HeLa cells.
    Concentration: 10 μM.
    Incubation Time: 48 hours.
    Result: Led to increased levels of LC3-II.
    分子量

    501.62

    Formula

    C30H35N3O4

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献

    BRD5631 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    BRD5631
    目录号:
    HY-125197
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