2. Neuronal Signaling
  3. Amyloid-β
  4. BuChE-IN-2

BuChE-IN-2 是一种优良的丁基胆碱酯酶 (BuChE) 抑制剂 (BuChE 与 NO 的 IC50s 分别为 1.28 μM 和 0.67 μM)。BuChE-IN-2 可抑制 Aβ 的聚集、ROS 的形成和螯合 Cu2+，具有适当的血脑屏障 (BBB) 穿透性。可用于研究阿尔茨海默病。

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BuChE-IN-2 Chemical Structure

BuChE-IN-2 Chemical Structure

CAS No. : 2745118-93-6

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BuChE-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BuChE-IN-2 is an excellent butyrylcholinesterase (BuChE) inhibitor (IC50s of 1.28 μM and 0.67 μM for BuChE and NO). BuChE-IN-2 can inhibit the aggregation of Aβ, ROS formation and chelate Cu2+, exhibiting proper blood-brain barrier (BBB) penetration. BuChE-IN-2 has potential to research Alzheimer’s disease[1].

IC50 & Target

IC50: 1.28 μM (BuChE), 0.67 μM (NO)[1]
体外研究
(In Vitro)

BuChE-IN-2 (compound f9) (5-50 μM; 24 hours) shows obvious neuroprotection on H2O2-induced PC12 cells at 20 μM[1].
BuChE-IN-2 (100 μM; 48 hours) can inhibit Aβ aggregation[1].
BuChE-IN-2 (0.1-20 μM; 24 hours) has the obviously inhibitory effect on the secretion of inflammatory factors and IL-1β (IC50=1.61 μM) and TNF-α (IC50=4.15 μM) in BV2 cells[1].
BuChE-IN-2 (1-10 μM; 1 hour) can significantly reduce the expression of COX-2 and iNOS in a concentration-dependent manner[1].
BuChE-IN-2 (1-50 μM; 6 hours) has a significant inhibitory effect on ROS accumulation at 20 μM[1].
BuChE-IN-2 (10-1000 μM; 2 hours) decreases the DPPH concentration dramatically from 86.09% to 34.62% when the concentration of BuChE-IN-2 increases from 10 μM to 1000 μM[1].
BuChE-IN-2 (75 μM; 2 hours; MDCKII-MDR1 cells) exhibits proper blood-brain barrier permeability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BuChE-IN-2 相关抗体:

Cell Cytotoxicity Assay

Cell Line: PC12 cells[1]
Concentration: 5, 20, 25, 50 μM
Incubation Time: 24 hour
Result: Showed obvious neuroprotection on H2O2-induced PC12 cells at 20 μM.

Western Blot Analysis

Cell Line: BV2 cells[1]
Concentration: 1, 3, and 10 μM
Incubation Time: 1 hour
Result: Significantly reduced the expression of COX-2 and iNOS in a concentration-dependent manner.
体内研究
(In Vivo)

BuChE-IN-2 (40.96-100 mg/kg; i.g., single) shows LD50 of 75.372 mg/kg in mice[1].
BuChE-IN-2 (10 and 30 mg/kg; i.g., single) can remarkably improve the cognitive impairment in scopolamine-induced mouse models according to Morris water maze experiment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL mice (8-week-old, 18-23 g)[1]
Dosage: 100, 80, 64, 51.2, 40.96 mg/kg
Administration: i.g.; single
Result: The median Lethal Dose (LD50) of BuChE-IN-2 was 75.372 (62.383-101.673) mg/kg (95% confidence limit).
Animal Model: Male C57BL mice (8-week-old, 18-23 g)[1]
Dosage: 30 mg/kg, 10 mg/kg
Administration: i.g., single
Result: BuChE-IN-2 could remarkably improve the cognitive impairment in scopolamine-induced mouse models according to Morris water maze experiment.
分子量

564.49

Formula

C28H20F4N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BuChE-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BuChE-IN-22745118-93-6Amyloid-ββ-amyloid peptideAβAbetaBuChEROSNeuroprotectionADBV2 cellsPC12 cellsInhibitorinhibitorinhibit

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