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Butabindide  (Synonyms: UCL-1397)

目录号: HY-150070
产品使用指南

Butabindide (UCL-1397) 是一种高效的选择性三肽肽酶II (TPP II) 抑制剂,对 TPP II 和 TPP I 的 Ki 值分别为 7 nM 和 10 μM。Butabindide 抑制 TPP II 以保护 CCK-8 不失活。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Butabindide oxalate 通常具有更好的水溶性和稳定性。

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Butabindide Chemical Structure

Butabindide Chemical Structure

CAS No. : 175553-48-7

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Butabindide 的其他形式现货产品:

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Other Forms of Butabindide:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation[1][2].

IC50 & Target

IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]

体外研究
(In Vitro)

Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) inhibits TPP II activity of cerebral membranes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Butabindide (UCL-1397; 10 mg/kg; i.v.; for 20 min) inhibits the breakdown of CCK-8 in the gastrointestinal tract and increases satiety in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (25-30 g)
Dosage: 10 mg/kg
Administration: Intravenous injection; for 20 minutes
Result: Reduces food intake and elicits other behavioral concomitants of satiation.
分子量

303.40

Formula

C17H25N3O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Butabindide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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