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  3. C14-490

C14-490是一种可离子化的阳离子脂质 (pKa = 5.94),用于合成脂质纳米颗粒 (LNPs)。C14-490 LNPs被用作后续在子宫内对造血干细胞 (HSCs) 进行基因编辑研究的基础。C14-490 LNPs用于包封SpCas9 mRNA和TTR sgRNA,采用优化的B5配方参数,并通过表面结合CD45抗体F(ab’)2 片段-系统优化的靶向编辑机械装置LNPs (STEM LNPs)。

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C14-490

C14-490 Chemical Structure

CAS No. : 2639634-82-3

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生物活性

C14-490, an ionizable cationic lipid (pKa = 5.94), is used for the synthesis of lipid nanoparticles (LNPs). C14-490 LNPs is used as the basis for subsequent study of in utero gene editing in HSCs. C14-490 LNPs are used to encapsulate SpCas9 mRNA and TTR sgRNA using optimized B5 formulation parameters and surface conjugation to CD45 antibody F(ab’)2 fragments-Systematically optimized Targeted Editing Machinery LNPs (STEM LNPs)[1].

分子量

1393.35

Formula

C86H177N5O7

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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产品名称:
C14-490
目录号:
HY-165604
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