2. Anti-infection
  3. Parasite
  4. C3361

C3361 是一种中度特异性的恶性疟原虫 (Plasmodium falciparum) 己糖转运蛋白 1 (PfHT1) 和伯氏疟原虫 (Plasmodium berghei) 己糖转运蛋白 1 (PbHT1) 抑制剂，Ki 值分别为 8.6 和 9.4 μM。C3361 还抑制 TgGT1，Ki 值为 8.6 和 82 μM。C3361 可抑制伯氏疟原虫肝脏期 (IC50 = 15 μM) 和动合子的发育。C3361 能够抑制血期寄生虫 (parasites) 的生长。C3361 可用于感染相关研究，如疟疾。

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C3361

C3361 Chemical Structure

CAS No. : 91042-00-1

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C3361 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

C3361 is a moderate specific Plasmodium falciparum hexose transporter 1 (PfHT1) and Plasmodium berghei hexose transporter 1 (PbHT1) inhibitor with Ki values of 8.6 and 9.4 μM. C3361 inhibits TgGT1 with a Ki of 82 μM. C3361 attenuates hepatic (IC50 = 15 μM) and ookinete development of P. berghei. C3361 can suppress the growth of blood-stage parasites. C3361 can be used for the research of infection, such as malaria[1][2].

体外研究
(In Vitro)

C3361 可使动合子形成减少 75%[1]。
C3361 (1-100 μM, 68 h) 可阻止子孢子感染的肝癌细胞中肝期裂殖体的成熟[1]。
C3361 对 P. berghei 有生长抑制作用， IC50 值为 15 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C3361 相关抗体:

Immunofluorescence[1]

Cell Line: Sporozoite-infected hepatoma cells
Concentration: 1, 10, 50 and 100 μM
Incubation Time: 68 h
Result: Decreased area of the liver schizonts.
体内研究
(In Vivo)

C3361 (2 mg/kg，静脉注射，每日一次) 可减少表达 GFP 的寄生虫感染的血细胞感染小鼠体内的寄生虫负荷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GFP-expressing parasite-infected blood cells infected mice models[1]
Dosage: 2 mg/kg
Administration: Intraperitoneally injection, daily
Result: Reduced 45% parasitemia from days 3-5.
分子量

332.43

Formula

C17H32O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

C3361 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C336191042-00-1C 3361C-3361ParasitePlasmodium falciparumPfHT1PbHT1MalariaInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-17656
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