1. Anti-infection
  2. Fungal
  3. Chitin synthase inhibitor 5

Chitin synthase inhibitor 5 (compound 9a) 是几丁质合成酶的抑制剂,IC50 值为 0.14 mM。Chitin synthase inhibitor 5 具有广谱的真菌抗性,对白色念珠菌、黄曲霉、烟毒念珠菌和新生念珠菌均有较好的抑制作用。Chitin synthase inhibitor 5 可用于真菌的研究中。

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Chitin synthase inhibitor 5 Chemical Structure

Chitin synthase inhibitor 5 Chemical Structure

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  • 生物活性

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生物活性

Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal[1].

IC50 & Target

IC50: 0.14 mM (chitin synthase)[1]

体外研究
(In Vitro)

Chitin synthase inhibitor 5 (300 μg/mL; 1 h) inhibits chitin synthase with an IC50 value of 0.14 mM[1].
Chitin synthase inhibitor 5 (1-512 μg/mL; 24 h) shows antifungal activities to C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 26.67, 32, 64 and 64 μg/mL, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

500.34

Formula

C23H22BrN3O5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Chitin synthase inhibitor 5 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Chitin synthase inhibitor 5
目录号:
HY-151410
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