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  2. Fungal
  3. Chitin synthase inhibitor 6

Chitin synthase inhibitor 6 (compound 9b) 是一种有效的 chitin synthase (CHS) 抑制剂,其 IC50 值为 0.21 mM,Chitin synthase inhibitor 6 对耐药真菌具有广谱抗真菌活性。Chitin synthase inhibitor 6 可用于真菌感染的研究。

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Chitin synthase inhibitor 6 Chemical Structure

Chitin synthase inhibitor 6 Chemical Structure

CAS No. : 3033645-29-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chitin synthase inhibitor 6 (compound 9b) is a potent chitin synthase (CHS) inhibitor with an IC50 value of 0.21 mM. Chitin synthase inhibitor 6 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 6 can be used in the research of fungi infection[1].

体外研究
(In Vitro)

Chitin synthase inhibitor 6 (compound 9b; 300 μg/mL) inhibits chitin synthase (CHS) activity with an inhibition percentage (IP) value of 82%[1].
Chitin synthase inhibitor 6 (1-512 μg/mL) has antifungal activity against four strains with minimum inhibitory concentration (MIC) values of 64, 64, 128, and 256 μg/mL for C. albicans, A. flavus, A. fumigatus, and C. neoformans, respectively[1].
Chitin synthase inhibitor 6 (0-256 μg/mL (50 μL), 24 h) shows strong synergistic effect against A. fumigatus when combinated with Fluconazole (HY-10219). Chitin synthase inhibitor 6 and fluconazole combination against C. neoformans (FIC = 0.625) and additive effect against C. albicans (FIC = 1.10). A. fumigatus (FIC = 1.125)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

451.47

Formula

C24H25N3O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献

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产品名称:
Chitin synthase inhibitor 6
目录号:
HY-151416
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