1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog
  3. CI 972 anhydrous

CI 972 anhydrous 是一会有效的,具有口服活性的,竞争性的嘌呤核苷磷酸化酶 (PNP) (Ki=0.83 μM) 抑制剂,正在开发作为 T 细胞选择性免疫抑制剂。

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CI 972 anhydrous Chemical Structure

CI 972 anhydrous Chemical Structure

CAS No. : 115787-68-3

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2].

IC50 & Target

Ki: 0.83 μM (PNP)[1]

体内研究
(In Vivo)

CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

297.76

Formula

C11H12ClN5OS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CI 972 anhydrous
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HY-118047
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