2. GPCR/G Protein
  3. Leukotriene Receptor
  4. CP-195543

CP-195543 是一种有效的选择性和具有口服活性的白三烯B4 LTB4 受体拮抗剂，对人中性粒细胞和小鼠脾脏膜的 IC50 值分别为 6.8、37.0 nM。CP-195543 阻断 CD11b 上调。CP-195543 抑制 LTB4 介导的中性粒细胞浸润。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CP-195543 Chemical Structure

CP-195543 Chemical Structure

CAS No. : 204981-48-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CP-195543 相关抗体

Top Publications Citing Use of Products

查看 Leukotriene Receptor 亚型特异性产品:

查看所有亚型
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration[1].

IC50 & Target[1]

LTB4

 

体外研究
(In Vitro)

CP-195543 抑制由 LTB4 介导的人和小鼠中性粒细胞趋化性，IC50 值分别为 2.4 nM、7.5 nM[1]。
CP-195543 (0.1 nM-10 µM；60 分钟) 阻断人中性粒细胞 (HN) 和小鼠中性粒细胞中 CD11b 的上调，对人单核细胞和嗜酸性粒细胞的 IC50 值分别为 270、420 nM [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CP-195543 相关抗体:
体内研究
(In Vivo)

CP-195543 (0.01, 0.1, 1, 10 mg/kg for guinea pig; 0.01, 0.1, 1, 10, 100 mg/kg for mice; P.o.; 1 h before injection of LTB4) 呈剂量依赖性抑制 LTB4 介导的中性粒细胞浸润[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea pig (Injection of LTB4 10, 30, 100 ng/site; injected intradermally)[1]
Dosage: 0.01, 0.1, 1, 10 mg/kg
Administration: P.o.; 1 h before injection of LTB4
Result: Inhibited LTB4-mediated neutrophil infiltration in guinea pigskin in a dose-dependent manner.
Animal Model: Mice (Injection of LTB4 100 ng/site; injected intradermally)[1]
Dosage: 0.01, 0.1, 1, 10, 100 mg/kg
Administration: P.o.; 1 h before injection of LTB4
Result: Inhibited LTB4-mediated neutrophil infiltration in guinea pigskin in a dose-dependent manner.
分子量

428.40

Formula

C24H19F3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP-195543 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-195543204981-48-6CP195543CP 195543Leukotriene Receptorhuman neutrophilsCD11bneutrophil infiltrationguinea piginflammatoryInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CP-195543
目录号：
HY-112742
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z