2. GPCR/G Protein Neuronal Signaling MAPK/ERK Pathway
  3. Neurokinin Receptor p38 MAPK
  4. CP-99994

CP-99994 是一种速激肽神经激肽 1 (NK-1) 受体拮抗剂，其 Ki 为 0.25 nM。CP-99994 可防止内脏高敏感情况下的结肠直肠致敏。CP-99994 在膀胱-结肠交叉致敏模型中降低了乙酸注射引起的结肠直肠致敏。CP-99994 减弱了与内脏高敏性相关的神经胶质相互作用和 MAPK-p38 磷酸化。

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CP-99994

CP-99994 Chemical Structure

CAS No. : 136982-36-0

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规格 是否有货
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Other Forms of CP-99994:

CP-99994 相关抗体

Top Publications Citing Use of Products

查看 Neurokinin Receptor 亚型特异性产品:

查看所有亚型
NK1R NK2R NK3R

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-99994 is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].

IC50 & Target[1]

NK1R

0.25 nM (Ki)

分子量

296.41

Formula

C19H24N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CP-99994 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-99994136982-36-0CP99994CP 99994Neurokinin Receptorp38 MAPKNK receptorTachykinin receptorAntagonistTachykinin neurokinin 1NK-1 ReceptorColorectal sensitizationNeuroglial interactionsMAPK-p38Bladder-colon cross-sensitization modelInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-12144
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