2. Anti-infection
  3. Parasite
  4. CRK12-IN-2

CRK12-IN-2 (compound 2) 是 CRK12 的抑制剂。CRK12-IN-2 对 Trypanosoma congolense 和 Trypanosoma vivax 具有效能，其 EC50 值分别为 3.2 和 0.08 nM。CRK12-IN-2 可用于动物锥体虫病的研究。

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CRK12-IN-2 Chemical Structure

CRK12-IN-2 Chemical Structure

CAS No. : 1990479-17-8

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CRK12-IN-2 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
L6 EC50
3600 nM
Compound: 2
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 69 hrs by resazurin dye based fluorescence analysis
Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 69 hrs by resazurin dye based fluorescence analysis
[PMID: 35303411]
体内研究
(In Vivo)

CRK12-IN-2 (10 mg/kg; s.c. once daily for 4 days) effectively cures mice with T. congolense- and T. vivax-infection[1].
1.19 Pharmacokinetic Properties of CRK12-IN-2 in Cattle[1].

Cattle
IV 2 mg/kg		 Cattle
IM 10 mg/kg
Clb (mL/min/kg) 15±5
Vdss (L/kg) 2.3±0.6
half-life (h) 4±2
AUC0-∞(ng·min/mL) 140000±40000 500000±30000
Cmax (ng/mL) 1700±800
Tmax (h) 1.3±0.6
F (%) 73±6

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with T. congolense and T. vivax infection[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; 10 mg/kg once daily; for 4 days
Result: Fully cured both T. congolense- and T. vivax-infected mice for 4 days at a dose of 10 mg/kg.
分子量

529.67

Formula

C23H33F2N5O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CRK12-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRK12-IN-21990479-17-8ParasitetrypanosomiasisTrypanosoma congolenseTrypanosoma vivaxcattlemiceInhibitorinhibitorinhibit

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目录号：
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