2. Immunology/Inflammation
  3. STING
  4. Dazostinag

Dazostinag  (Synonyms: TAK-676 free base)

目录号: HY-152861
产品使用指南

摩尔计算器

Dazostinag (TAK-676 free base) 是干扰素基因刺激剂 (STING) 蛋白的激动剂，具有抗肿瘤活性。Dazostinag 可作为有效载荷 (playload) 用于合成抗体偶联活性分子 (ADC)。

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Dazostinag Chemical Structure

Dazostinag Chemical Structure

CAS No. : 2553413-86-6

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Other Forms of Dazostinag:

Dazostinag 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs)[1][2].

体外研究
(In Vitro)

Dazostinag (ADC-1，连接子-有效载荷) (121 μM；10 min-24 hr) 在大鼠肝脏三倍体中的半衰期 (t1/2) 为 2.4 小时[1]。
Dazostinag (ADC-1，连接子-有效载荷) 在具有人 STING 的 R232 变体的 THP1 细胞中激活人鸟苷酸环化酶 C (GCC)，EC50 为 0.068 nM[1]。
Dazostinag (ADC-1) (10 μg/mL；0-96 小时) 在人、灵长类动物和小鼠血浆中表现出血浆稳定性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dazostinag 相关抗体:
体内研究
(In Vivo)

Dazostinag (ADC-1) (0.1 mg/kg；单剂量) 在携带 CT26-GCC 肿瘤的 Balb/C 小鼠中，半衰期为 33 小时，AUC (last) 值为 51432 h·nM[1]。
Dazostinag (ADC-1) (50 μg/kg，100 μg/kg；静脉注射；单剂量，监测 2 周) 显著抑制 Balb/C 小鼠中、表达 GCC 的 CT26 结肠癌小鼠肿瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CT26 colon carcinoma model in female Balb/C mice (6-8 weeks old)[1]
Dosage: 50 μg/kg, 100 μg/kg
Administration: IP; single dose, monitored for 15 days, measured two times per week
Result: Significantly suppressed the volume of tumor in mice.
Clinical Trial
分子量

710.52

Formula

C21H22F2N8O10P2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Dazostinag 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dazostinag2553413-86-6TAK-676TAK676TAK 676STINGStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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