2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK p38 MAPK
  4. DCZ19931

DCZ19931 是一种有效的多靶向激酶抑制剂。DCZ19931 对眼部新生血管有抗血管生成作用。DCZ19931 还抑制 ERK1/2-MAPK 和 p38-MAPK 信号。

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DCZ19931 Chemical Structure

DCZ19931 Chemical Structure

CAS No. : 2789629-84-9

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DCZ19931 相关抗体

Top Publications Citing Use of Products

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling[1].

IC50 & Target[1]

ERK1

 

ERK2

 

p38 MAPK

 

体外研究
(In Vitro)

DCZ19931 (1 nM-10 μM; 24 h) 对人脐静脉内皮细胞 (HUVECs) 无明显的细胞毒性[1]。
DCZ19931 (500 nM; 24 h) 抑制 (10 ng/mL; 12 h) VEGFs 诱导的内皮细胞增殖、迁移和成管能力[1]。
DCZ19931 (500 nM; 24 h) 通过下调 ICAM-1，表达抑制血管通透性[1]。
DCZ19931 (500 nM; 24 h) 降低 HUVECs 中 p-ERK1/2、p-p38 和 p-JNK 的表达水平[1]。
DCZ19931 在小鼠脉络膜发芽试验中也显示出抗血管生成作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DCZ19931 相关抗体:

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 500 nM; with or without 50 ng/mL VEGF for 30 min
Incubation Time: 24 hours
Result: Decreased expression of phosphorylated ERK and phosphorylated p38.
体内研究
(In Vivo)

DCZ19931 (1 μL, 1 μg/μL; 静脉注射; 单剂量) 抑制小鼠氧诱导视网膜病变 (OIR) 模型眼新生血管生成[1].
DCZ19931 (2 μL, 1 μg/μL; 静脉注射; 7 d) 无组织毒性，并抑制激光诱导脉络膜新生血管 (CNV) 模型小鼠的眼部新生血管生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Laser-induced choroidal neovascularization (CNV) model in mice[1]
Dosage: 2 μL, 1 μg/μL
Administration: Intravitreal injection; single dose, monitored for 7 d following laser photocoagulation
Result: Did not cause marked histopathological changes in retinal structures.
Decreased the areas of CNV lesions, showed anti-angiogenic effect in vivo.
Animal Model: Oxygen-induced retinopathy (OIR) model in mice[1]
Dosage: 1 μL, 1 μg/μL
Administration: Intravitreal injection; single dose
Result: Further showed anti-angiogenic effect in vivo, inhibited ocular neovascularization.
分子量

549.45

Formula

C26H20F5N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DCZ19931 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCZ199312789629-84-9DCZ 19931DCZ-19931ERKp38 MAPKExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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HY-152087
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