2. Antibody-drug Conjugate/ADC Related Apoptosis
  3. Transferrin Receptor Antibody-Oligonucleotide Conjugates (AOCs)
  4. Delpacibart braxlosiran

Delpacibart braxlosiran  (Synonyms: Del-brax; AOC 1020)

目录号: HY-177566
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Delpacibart braxlosiran (Del-brax) 是一种抗体寡核苷酸结合物。它由一种靶向转铁蛋白受体 1 (TfR1) 的单克隆抗体 (Delpacibart) (HY-P990051) 和靶向 DUX4 (双同源框蛋白) mRNA 的 siRNA 组成，用于面肩肱型肌营养不良症 (FSHD) 的研究。DUX4 蛋白的异常表达会导致肌肉细胞中基因表达的变化，这种变化与 FSHD 肌肉功能丧失有关。

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Delpacibart braxlosiran

Delpacibart braxlosiran Chemical Structure

CAS No. : 2929261-85-6

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Delpacibart braxlosiran 相关抗体

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  • 生物活性

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生物活性

Delpacibart braxlosiran (Del-brax), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrin receptor 1 (TfR1) conjugated with a siRNA targeting DUX4 (Double homeobox protein) mRNA. It is used for the study of Facioscapulohumeral Muscular Dystrophy (FSHD). The abnormal expression of DUX4 protein leads to changes in gene expression in muscle cells that are associated with the life-long, progressive loss of muscle function in patients with FSHD[1].

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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献

Delpacibart braxlosiran 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delpacibart braxlosiran2929261-85-6Del-brax AOC 1020AOC1020AOC 1020AOC-1020Transferrin ReceptorAntibody-Oligonucleotide Conjugates (AOCs)TfRCD71Inhibitorinhibitorinhibit

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