1. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  2. Reactive Oxygen Species Apoptosis
  3. Didocosahexaenoin

Didocosahexaenoin  (Synonyms: 二十二碳六烯酸甘油二酯)

目录号: HY-148944
产品使用指南

Didocosahexaenoin 是一种 omega-3 衍生物,是 DHA 的甘油二酯,可由 DHA 甘油三酯合成。Didocosahexaenoin 导致线粒体膜电位显着丧失并诱导 ROS 产生。Didocosahexaenoin 诱导细胞凋亡。Didocosahexaenoin 在人前列腺癌细胞中诱导比 DHA 更强的细胞毒性。

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Didocosahexaenoin Chemical Structure

Didocosahexaenoin Chemical Structure

CAS No. : 124538-05-2

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规格 价格 是否有货 数量
1 mg ¥1426
3 - 4 周
5 mg   询价  
10 mg   询价  

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Didocosahexaenoin, an omega-3 derivative, is a diglyceride of DHA and can be synthesised from DHA triglycerides. Didocosahexaenoin causes significant loss of mitochondrial membrane potential and induces ROS production. Didocosahexaenoin induces apoptosis. Didocosahexaenoin induces stronger cytotoxicity than DHA in human prostate carcinoma cells[1].

体外研究
(In Vitro)

二十二碳六烯酸甘油二酯 (10-50 μM; 96 小时) 诱导 PC3 细胞凋亡[1]
二十二碳六烯酸甘油二酯 (1 nM-100 μM; 96 小时) 对人前列腺细胞诱导剂量依赖性细胞毒性[1]
二十二碳六烯酸甘油二酯 (30, 50 μM; 24 小时) 导致线粒体膜电位损失显着增加[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: PC3 cells
Concentration: 10, 20, 30, 40, 50 μM
Incubation Time: 24, 48 hours
Result: Caused elevated levels of early apoptotic cells.
Significantly increased the level of activated caspase 3/7 for 6 h at 30 and 50 μM.

Cell Cytotoxicity Assay[1]

Cell Line: PC3, DU145, A2780 and A2780-CP70 carcinoma cells and MCF-7 and LNCaP cells
Concentration: 1 nM-100 μM
Incubation Time: 96 hours
Result: Induced dose-dependent cytotoxicity with the strongest toxicity under 10.0 μM on DU145 and PC3 cells, A2780 and A2780-CP70 with IC50 of 3.20 and 3.82 μM, 4.6, 5.53 μM, respectively.
分子量

420.58

Formula

C25H40O5

CAS 号
中文名称

二十二碳六烯酸甘油二酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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