2. Anti-infection
  3. Enterovirus
  4. Disoxaril

Disoxaril (WIN-51711) 是一种脊髓灰质炎病毒抑制剂。Disoxaril 可抑制 1 型和 2 型脊髓灰质炎病毒在细胞中的复制。 Disoxaril 可直接与病毒衣壳蛋白结合，并通过稳定病毒衣壳来抑制病毒脱壳。Disoxaril 仍允许病毒通过受体介导的内吞作用进入细胞。Disoxaril 还可抑制肠道病毒的复制。

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Disoxaril Chemical Structure

Disoxaril Chemical Structure

CAS No. : 87495-31-6

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Disoxaril 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Disoxaril (WIN-51711) is a polioviruses inhibitor. Disoxaril inhibits the replication of polioviruses types 1 and 2 in cells. Disoxaril binds directly to the virion capsid proteins and inhibits viral uncoating by stabilizing the virus capsid. Disoxaril still allows the virus to enter the cell by receptor-mediated endocytosis. Disoxaril also inhibits enterovirus replication[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa CC50
37 μM
Compound: WIN-51711
Compound concentration required to reduce the viability of mock-infected HeLa cells by 50%, was reported.
Compound concentration required to reduce the viability of mock-infected HeLa cells by 50%, was reported.
[PMID: 7877145]
RD EC50
15.32 μM
Compound: 5; WIN 51711
Antiviral activity against Enterovirus 71 infected in human RD cells after 24 to 36 hrs by MTS-based CPE reduction assay
Antiviral activity against Enterovirus 71 infected in human RD cells after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
RD CC50
167.39 μM
Compound: 5; WIN 51711
Cytotoxicity against human RD cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
Cytotoxicity against human RD cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
Vero CC50
147.77 μM
Compound: 5; WIN 51711
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 24 to 36 hrs by MTS-based CPE reduction assay
[PMID: 26885567]
Vero EC50
19.48 μM
Compound: 5; WIN 51711
Antiviral activity against Human enterovirus 71 infected in monkey African green Vero cells by MTS-based CPE reduction assay
Antiviral activity against Human enterovirus 71 infected in monkey African green Vero cells by MTS-based CPE reduction assay
[PMID: 26885567]
分子量

342.43

同用名

WIN-51711

Formula

C20H26N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Disoxaril 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Disoxaril87495-31-6WIN-51711WIN51711WIN 51711EnterovirusRhinovirusHRVHRVsHEVHEVspolioviruseenterovirusInhibitorinhibitorinhibit

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