2. Anti-infection
  3. Parasite
  4. DXR-IN-1

DXR-IN-1 (Compound 13E) 是 1- 脱氧 -D- 酮糖 5- 磷酸还原异构酶 (DXR) 的抑制剂。对恶性疟原虫的 DXR 具有高度选择性 (IC50=0.030 μM)。DXR-IN-1 通过与 DXR 活性位点结合并阻止其催化活动，从而抑制疟原虫的生长。

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DXR-IN-1 Chemical Structure

DXR-IN-1 Chemical Structure

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DXR-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DXR-IN-1 (Compound 13E) is an inhibitor of 1-deoxy-D-ketose 5-phosphate reductoisomerase (DXR). DXR-IN-1 is highly selective for P. falciparum DXR (IC50=0.030 μM). DXR-IN-1 inhibits the growth of P. falciparum by binding to the active site of DXR and blocking its catalytic activity[1].

体外研究
(In Vitro)

DXR-IN-1 对 DXR 的抑制效果分别为 IC50=0.035 μM (E. col)， 3.0 μM (M. tuberculosis)[1]。
DXR-IN-1 抗疟原虫活性 分别为 IC50=0.55 μM (Pf3D7)， 0.94 μM (PfDd2)[1]。
DXR-IN-1 的细胞毒性为 IC50=>1000 μM (HepG-2)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DXR-IN-1 相关抗体:
分子量

377.37

Formula

C19H24NO5P
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DXR-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DXR-IN-1ParasitefosmidomycinN-substituted hydroxamic acids1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXRIspC)nonmevalonate biosynthesis pathwayantiplasmodial activitycocrystal structureInhibitorinhibitorinhibit

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产品名称：
DXR-IN-1
目录号：
HY-158335
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