2. Apoptosis
  3. TNF Receptor
  4. (E)-C-HDMAPP ammonium

(E)-C-HDMAPP ammonium 是一种铵盐形式的强效磷抗原，也是 (E)-HDMAPP 的焦磷酸盐形式。(E)-C-HDMAPP 还是 γδ T 细胞的有效激活因子，可在体外诱导 T 细胞的刺激反应 (EC50=0.91 nM, TNF-α)。

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(E)-C-HDMAPP ammonium Chemical Structure

(E)-C-HDMAPP ammonium Chemical Structure

CAS No. : 933030-60-5

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规格 价格 是否有货 数量
1 mg ￥3002
3 - 4 周
5 mg   询价  
10 mg   询价  

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(E)-C-HDMAPP ammonium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release)[1][2].

IC50 & Target[1]

TNFRSF1A

 

体外研究
(In Vitro)

(E)-C-HDMAPP (化合物 5E) (2 μM) 增加原代多克隆人 Vγ9Vδ2 T 细胞中的 TNF-α 释放水平，并具有刺激性生物活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-C-HDMAPP ammonium 相关抗体:
体内研究
(In Vivo)

(E)-C-HDMAPP (化合物 5E) (0.02-10 mg/kg；静脉注射；15 天) 显着增加食蟹猴模型中的 γδ 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nonhuman Primate Model in Cynomolgus[1]
Dosage: 0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg, and 10 mg/kg
Administration: Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
Result: Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 5 mg/kg and 10 mg/kg.
分子量

311.21

Formula

C6H23N3O7P2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(E)-C-HDMAPP ammonium 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-C-HDMAPP933030-60-5TNF ReceptorTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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