2. Immunology/Inflammation
  3. STING
  4. E7766 disodium

E7766 disodium 是一种大环桥连 STING 激动剂，Kd 为 40 nM。E7766 disodium 显示出强大的泛基因型和抗肿瘤活性。

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E7766 disodium Chemical Structure

E7766 disodium Chemical Structure

CAS No. : 2242636-28-6

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E7766 disodium 的其他形式现货产品:

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E7766 disodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

E7766 disodium is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 disodium shows potent pan-genotypic and antitumor activities[1].

体外研究
(In Vitro)

E7766 disodium inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

E7766 disodium 相关抗体:
体内研究
(In Vivo)

In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 disodium in the subcutaneous tumor. E7766 disodium is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

792.58

Formula

C24H26F2N10Na2O8P2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

E7766 disodium 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E7766 disodium2242636-28-6STINGStimulator of Interferon GenesTMEM173MITAERISMPYSpan-genotypicantitumormacrocycleInhibitorinhibitorinhibit

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E7766 disodium
目录号：
HY-111999B
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