2. Immunology/Inflammation
  3. Complement System
  4. Factor B-IN-5

Factor B-IN-5 是一种口服有效的补体因子 B (CFB) 抑制剂。Factor B-IN-5 通过抑制补体系统的过度激活和改善线粒体功能来减轻糖尿病肾病的肾脏损伤。Factor B-IN-5 可以改善肾小管间质炎症和纤维化。Factor B-IN-5 可用于糖尿病肾病的研究。

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Factor B-IN-5

Factor B-IN-5 Chemical Structure

CAS No. : 1644670-23-4

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Factor B-IN-5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy[1].

体内研究
(In Vivo)

Factor B-IN-5 (20 和 60 mg/kg；灌胃；每天两次；持续 10 周) 改善了雄性糖尿病 db/db C57BL/6J 小鼠的肾小管间质炎症并且减少了肾损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male diabetic db/db C57BL/6J mice (C57BL/6J-LepRdb/db) (6 weeks)[1]
Dosage: 20 and 60 mg/kg
Administration: Oral gavage (i.g.); twice daily for 10 weeks
Result: Significantly reduced the level of uACR.
Significantly improved renal tubulointerstitial fibrosis and atrophy.
Significantly reduced the thickness of glomerular basement membrane (GBM).
Reduced the expression of inflammatory markers Kim-1 and IL-1β.
Improved mitochondrial morphology and dynamics and upregulated the expression of Mfn2 and Prkn.
Might exert its effect by regulating CASP3 and DPP4.
分子量

392.49

Formula

C24H28N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Factor B-IN-5 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Factor B-IN-51644670-23-4Complement SystemCFBinflammationdiabetic nephropathymitochondriadb/db micediabetes mellituInhibitorinhibitorinhibit

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