2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Fluparoxan hydrochloride

Fluparoxan hydrochloride  (Synonyms: GR50360 hydrochloride)

目录号: HY-106769A
产品使用指南

摩尔计算器

Fluparoxan hydrochloride 是一种具有口服活性、选择性和竞争性的 α2-肾上腺素受体拮抗剂。Fluparoxan hydrochloride 是一种抗抑郁剂。

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Fluparoxan hydrochloride Chemical Structure

Fluparoxan hydrochloride Chemical Structure

CAS No. : 105226-30-0

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Other Forms of Fluparoxan hydrochloride:

Fluparoxan hydrochloride 相关抗体

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fluparoxan hydrochloride is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan hydrochloride is an anti-depressant agent[1][2].

IC50 & Target

α2-adrenergic receptor

 

体外研究
(In Vitro)

在大鼠离体、场刺激输精管和豚鼠离体、场刺激回肠制剂中，Fluparoxan 是 α2-肾上腺素受体激动剂 UK-14304 (HY-B0659) 抑制反应的可逆竞争性拮抗剂，pKB 值分别为 7.87 和 7.89[1]。
在大鼠离体尾尾肌中，Fluparoxan 是一种较弱的竞争性拮抗剂，可对抗 α1-肾上腺素受体激动剂 phenylephrine (HY-B0769) 的收缩反应，pKB 为 4.45，α2: α1-肾上腺素受体选择性比大于 2500[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fluparoxan hydrochloride 相关抗体:
体内研究
(In Vivo)

在清醒小鼠中，Fluparoxan (0.2-3.0 mg/kg) 通过口服途径有效，并且在预防 clonidine (HY-12721) 引起的体温过低和抗伤害方面与 idazoxan (HY-14561) 具有相似的效力[1]。
Fluparoxan (0.67-6 mg/kg，口服)可预防 UK-14304 (HY-B0659) 引起的狗镇静和心动过缓[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

231.65

Formula

C10H11ClFNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fluparoxan hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluparoxan105226-30-0GR50360GR 50360GR-50360Adrenergic ReceptorBeta Receptoralpha 2-adrenoceptororally activeInhibitorinhibitorinhibit

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目录号：
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