1. Autophagy
  2. Autophagy
  3. Forigerimod

Forigerimod  (Synonyms: IPP-201101)

目录号: HY-105037
产品使用指南

Forigerimod (IPP-201101) 是一种 CD4 T 细胞调节剂。Forigerimod 是 U1 小核核糖核蛋白 70 kDa 的 21 个氨基酸片段,在 Ser140 位点被磷酸化。Forigerimod 可以有效抑制自噬。Forigerimod 可用于系统性红斑狼疮 (SLE) 等自身免疫性疾病的研究。

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Forigerimod Chemical Structure

Forigerimod Chemical Structure

CAS No. : 497156-60-2

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Forigerimod 的其他形式现货产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Forigerimod (IPP-201101) is a CD4 T-cell modulator. Forigerimod is a 21-amino-acid fragment of U1 small nuclear ribonucleoprotein 70 kDa that is phosphorylated at Ser140. Forigerimod can potently inhibit autophagy. Forigerimod can be used for the research of autoimmune disorders, such as systemic lupus erythematosus (SLE) [1][2][3][4].

体内研究
(In Vivo)

Forigerimod (P140) (i.v.; 100 μg in 100 μL saline per mouse) 直接作用于分子伴侣介导的自噬,使 MRL/lpr 小鼠免于唾液腺中发生的细胞浸润和自噬缺陷[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRL/lpr mice[4]
Dosage: 100 μg in 100 μL saline per mouse
Administration: Intravenous administration, single
Result: Corrected the cell content and distribution in MRL/lpr salivary glands.
Corrected the defective of autophagy processes in SGs of MRL/lpr mice.
分子量

2638.94

Formula

C117H181N34O32PS

CAS 号
Sequence

Arg-Ile-His-Met-Val-Tyr-Ser-Lys-Arg-{pSer}-Gly-Lys-Pro-Arg-Gly-Tyr-Ala-Phe-Ile-Glu-Tyr

Sequence Shortening

RIHMVYSKR-{pSer}-GKPRGYAFIEY

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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