2. Anti-infection
  3. Beta-lactamase Bacterial
  4. FPI-1523

FPI-1523 是 Avibactam 的衍生物，是一种有效的 β-内酰胺酶抑制剂，对 CTX-M-15 和 OXA-48 的 Kd 值分别为 4 nM 和 34 nM。FPI-1523 还抑制 PBP2，IC50 值为 3.2 μM。FPI-1523 显示出相当大的抗菌活性。

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FPI-1523 Chemical Structure

FPI-1523 Chemical Structure

CAS No. : 1452459-50-5

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FPI-1523 相关抗体

Top Publications Citing Use of Products

查看 Beta-lactamase 亚型特异性产品:

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Metallo-β-lactamase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 exhibits considerable antimicrobial activity[1].

IC50 & Target

β-lactamase[1]
体外研究
(In Vitro)

FPI-1523 inhibits K12 E. coli K12 and PBP2, with MIC and IC50 of 4 μg/mL and 0.4 μg/mL, respectively[1].
FPI-1523 inhibit E. coli BW25113 pGDP-2 transformants either with an empty vector or expressing different β-lactamases, with low MICs (1-2 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FPI-1523 相关抗体:
分子量

322.30

Formula

C9H14N4O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FPI-1523 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FPI-15231452459-50-5FPI1523FPI 1523Beta-lactamaseBacterialβ-lactamaseAvibactamCTX-M-15OXA-48PBP2antimicrobialInhibitorinhibitorinhibit

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目录号：
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