2. Anti-infection
  3. Bacterial
  4. FtsZ-IN-8

FtsZ-IN-8 是一种有效的 FtsZ 抑制剂，可促进 FtsZ 聚合并抑制 FtsZ 的 GTPase 活性。因此，FtsZ-IN-8 抑制细菌分裂导致细菌细胞死亡。FtsZ-IN-8 显示出杀菌活性，没有明显的引发细菌耐药性的趋势以及快速杀菌特性。并且 FtsZ-IN-8 对哺乳动物细胞表现出低溶血活性和细胞毒性。

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FtsZ-IN-8 Chemical Structure

FtsZ-IN-8 Chemical Structure

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FtsZ-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FtsZ-IN-8 is a potent FtsZ inhibitor, to promote FtsZ polymerization and inhibit GTPase activity of FtsZ. Thus, FtsZ-IN-8 inhibits bacterial division to lead to death of bacterial cells. FtsZ-IN-8 shows bactericidal activity with no significant tendency to trigger bacterial resistance as well as rapid bactericidal properties. And FtsZ-IN-8 shows low hemolytic activity and cytotoxicity to mammalian cells[1].

体外研究
(In Vitro)

FtsZ-IN-8 (compound B16) 抑制测试的革兰氏阳性菌，包括耐甲氧西林金黄色葡萄球菌 (MRSA) (MIC=0.098 μg/mL)、枯草芽孢杆菌 (MIC=0.098 μg/mL) 和肺炎链球菌 (MIC=0.39 μg/mL)[1]。
FtsZ-IN-8 (1-4× MIC；0-24 h) 抑制 MRSA 细菌生长。并且 FtsZ-IN-8 (4× MIC; 4 h) 扰乱了 MRSA ATCC43300 的细胞表面，使其表面出现明显的皱纹和丝状结构[1]。
FtsZ-IN-8 (4 μg/mL; 10 min; 25 ℃) 促进 FtsZ 聚合并 (0.02-0.64 μg/mL; 30 min) 剂量依赖性地抑制 FtsZ 的 GTPase 活性[1]。
FtsZ-IN-8 (12.5 μg/mL; 1 h; 37 ℃) 对人红细胞 RAW264.7 细胞的溶血活性可忽略不计[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FtsZ-IN-8 相关抗体:

Cell Viability Assay[1]

Cell Line: MRSA ATCC43300
Concentration: 1 × , 2 × , 4 × MIC; MIC=0.098 μg/mL
Incubation Time: 0 h, 0.5 h, 1 h, 1.5 h, 2 h, 4 h, 6 h, 8 h, 12 h, 22 h, and 24 h
Result: Inhibited the growth of bacteria, and more fast compared with Vancomycin (HY-B0671).
分子量

506.43

Formula

C27H28BrN3O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FtsZ-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FtsZ-IN-8BacterialFtsZFtsZ polymerizationGTPase activitybacterial divisionbactericidal activityhemolytic activitycytotoxicityInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-149226
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