2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. GABAA receptor modulator-8

GABAA receptor modulator-8 (10c) 是可透过血脑屏障的、选择性的 GABAA 受体阳性调节剂，具有抗癫痫活性。

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GABAA receptor modulator-8 Chemical Structure

GABAA receptor modulator-8 Chemical Structure

CAS No. : 2889382-34-5

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GABAA receptor modulator-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GABAA receptor modulator-8 (10c) is a blood-brain barrier penetrated, selective and positive modulator of GABAA receptor, with excellent antiepileptic activity[1].

药代动力学
(Parmacokinetics)[1]
Species Dose Route Indicator value
Rat 10 mg/kg i.g. Tmax 4 hr
Rat 10 mg/kg i.v. T1/2 2.47±0.14 hr
Rat 30 mg/kg i.g. Tmax 4 hr
Rat 30 mg/kg i.v. T1/2 2.49±0.07 hr
Rat 10 mg/kg i.g. Cmax 587.67±12.66 ng/mL
Rat 10 mg/kg i.v. MRT0-t 3.65±0.30 hr
Rat 30 mg/kg i.g. Cmax 1521.25±100.76 ng/mL
Rat 30 mg/kg i.v. MRT0-t 3.86±0.06 hr
Rat 10 mg/kg i.g. T1/2 2.53±0.12 hr
Rat 10 mg/kg i.v. AUC0-t 34,263.98±1100.87 ng/L.h
Rat 30 mg/kg i.g. T1/2 2.57±0.09 hr
Rat 30 mg/kg i.v. AUC0-t 107,689.72±6779.70 ng/L.h
Rat 10 mg/kg i.g. MRT0-t 4.57±0.09 hr
Rat 10 mg/kg i.v. AUC0-∞ 34,341.50±908.33 ng/L.h
Rat 30 mg/kg i.g. MRT0-t 5.37±0.32 hr
Rat 30 mg/kg i.v. AUC0-∞ 108,414.07±5853.89 ng/L.h
Rat 10 mg/kg i.g. AUC0-t 3201.38±82.07 ng/L.h
Rat 30 mg/kg i.g. AUC0-t 11,273.22±703.84 ng/L.h
Rat 10 mg/kg i.g. AUC0-∞ 3202.48±80.91 ng/L.h
Rat 30 mg/kg i.g. AUC0-∞ 11,328.84±574.48 ng/L.h
Rat 10 mg/kg i.g. F 9.34±0.07 %
Rat 30 mg/kg i.g. F 10.47±0.10 %
体内研究
(In Vivo)

GABAA receptor modulator-8 (10c) 在最大电休克 (MES) 模型中，表现出优异的抗癫痫活性，ED50 值为 8.51 mg/kg。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

348.37

Formula

C20H17FN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GABAA receptor modulator-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GABAA receptor modulator-82889382-34-5GABAA receptor modulator8GABAA receptor modulator 8GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAA receptorantiepilepticmaximal electroshockInhibitorinhibitorinhibit

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