1. Cytoskeleton
  2. Gap Junction Protein
  3. Danegaptide

Danegaptide (Synonyms: GAP-134; ZP 1609)

目录号: HY-10913
产品使用指南

Danegaptide (GAP-134) 是一种有效的,选择性的,具有口服活性的 gap-junction 修饰剂,具有抗心律不齐的作用。

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Danegaptide Chemical Structure

Danegaptide Chemical Structure

CAS No. : 943134-39-2

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Description

Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].

IC50 & Target

Gap junction.

In Vitro

Danegaptide (GAP-134, compound 9f; 0.01 nM-100 μM) dose dependently reduces dye uptake in cultured C6 glioma cells in a manner[1].

In Vivo

Danegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl2 model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl2[1].
Danegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles[2].

Clinical Trial
Molecular Weight

291.30

Formula

C₁₄H₁₇N₃O₄

CAS No.

943134-39-2

SMILES

O=C(N[C@H]1CN(C(CN)=O)[C@H](C(O)=O)C1)C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DanegaptideGAP-134ZP 1609GAP134GAP 134ZP1609ZP-1609Gap Junction ProteinCardioprotectiveantiarrhythmicorallydipeptideInhibitorinhibitorinhibit

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产品名称:
Danegaptide
目录号:
HY-10913
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