SIRPB1 - signal regulatory protein beta 1 Gene

中文名称：信号调节蛋白β1

种属: Homo sapiens

同用名: CD172b; SIRP-BETA-1

关于 SIRPB1

功能概要

该基因编码的蛋白质是信号调节蛋白 (SIRP) 家族的一员，也属于免疫球蛋白超家族。 SIRP 家族成员是受体型跨膜糖蛋白，已知参与受体酪氨酸激酶偶联信号传导过程的负调节。发现该蛋白质与 TYROBP/DAP12 相互作用，TYROBP/DAP12 是一种带有免疫受体酪氨酸激活基序的蛋白质。据报道，该蛋白质还参与了酪氨酸激酶 Syk 的募集。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 2 月]

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase Syk. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]