TYROBP - transmembrane immune signaling adaptor TYROBP Gene

中文名称：跨膜免疫信号转导接头 TYROBP

种属: Homo sapiens

同用名: DAP12; KARAP; PLOSL; PLOSL1

基因 ID: 7305 | 基因类型: protein coding

关于 TYROBP

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,904,403-35,908,295 (from NCBI)

This gene has 9 transcripts (splice variants), 101 orthologues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 147.9), spleen (RPKM 124.2) and 20 other tissues.

功能概要

该基因编码跨膜信号多肽，该多肽在其细胞质结构域中包含基于免疫受体酪氨酸的激活基序 (ITAM) 。编码的蛋白质可能与膜糖蛋白的杀伤细胞抑制受体 (KIR) 家族相关联，并可能充当激活信号转导元件。这种蛋白质可能结合 zeta 链 (TCR) 相关蛋白激酶 70kDa (ZAP-70) 和脾脏酪氨酸激酶 (Syk) ，并在信号转导、骨骼建模、脑髓鞘形成和炎症中发挥作用。该基因内的突变与多囊性脂膜性骨发育不良伴硬化性白质脑病 (PLOSL) ，也称为 Nasu-Hakola 病有关。其推定的受体，即髓样细胞 2 (TREM2) 上表达的触发受体，也会引起 PLOSL。已经为该基因鉴定了编码不同亚型的多个替代转录物变体。[RefSeq 提供，2010 年 3 月]

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (Syk) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

TYROBP 基因产物(4)

mRNA	Protein	Name
NM_001173514.2	NP_001166985.1	TYRO protein tyrosine kinase-binding protein isoform 3 precursor
NM_001173515.2	NP_001166986.1	TYRO protein tyrosine kinase-binding protein isoform 4 precursor
NM_003332.4	NP_003323.1	TYRO protein tyrosine kinase-binding protein isoform 1 precursor
NM_198125.3	NP_937758.1	TYRO protein tyrosine kinase-binding protein isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	20890284	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	10799849	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9655483	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	9655483	GOA
enables protein-macromolecule adaptor activity	IDA IDA: 通过直接分析推断	23459077	GOA
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	11602640	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in amyloid-beta clearance	IDA IDA: 通过直接分析推断	27477018	GOA
involved in cellular response to amyloid-beta	IDA IDA: 通过直接分析推断	23459077	GOA
involved in myeloid leukocyte activation	IDA IDA: 通过直接分析推断	10604985	GOA
involved in negative regulation of B cell proliferation	IMP IMP: 通过突变表型推断	21727189	GOA
involved in negative regulation of type I interferon production	IDA IDA: 通过直接分析推断	26358190	GOA
acts upstream of or within osteoclast differentiation	IMP IMP: 通过突变表型推断	21841309	GOA
involved in positive regulation of macrophage fusion	IMP IMP: 通过突变表型推断	18957693	GOA
involved in positive regulation of protein localization to cell surface	IMP IMP: 通过突变表型推断	23715743	GOA
involved in protein stabilization	IDA IDA: 通过直接分析推断	25957402	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	23715743	GOA
involved in stimulatory C-type lectin receptor signaling pathway	IDA IDA: 通过直接分析推断	9655483	GOA
involved in stimulatory killer cell immunoglobulin-like receptor signaling pathway	IDA IDA: 通过直接分析推断	9655483	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cell surface	IDA IDA: 通过直接分析推断	10799849	GOA
located in cell surface	IDA IDA: 通过直接分析推断	15294961	GOA
is active in plasma membrane	IDA IDA: 通过直接分析推断	23459077	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	9655483	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

TYRO protein tyrosine kinase-binding protein

DNAX adaptor protein 12

TYROBP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TYROBP	O43914	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
种属内	TYROBP	O43914	TMEM86A	Homo sapiens	Q8N2M4	Validated Y2H	32296183
种属内	TYROBP	O43914	TYROBP	Homo sapiens	O43914	NMR	20890284
种属内	TYROBP	O43914	TYROBP	Homo sapiens	O43914	Comig Non-Denat Gel	20890284
种属内	TYROBP	O43914	SIRPB1	Homo sapiens	O00241	Anti Bait CoIP	10940905
种属内	TYROBP	O43914	SIRPB1	Homo sapiens	O00241	Anti Tag CoIP	10940905
种属内	TYROBP	O43914	dap12-tm_nkg2c-tm_fusion_protein	Homo sapiens	EBI-16420154	NMR	20890284

种属间: 跨种属相互作用 种属内: 同种属相互作用

TYROBP 抗体

目录号	产品名	应用	反应物种
HY-P81906	DAP12 Antibody (YA1651)	WB, IHC-P, ICC/IF, FC	Human

关联疾病

疾病名称

别名

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Solitary Bone Cyst

Unicameral Bone Cyst	Bone Cysts
Cyst Of Bone	Local Cyst Of Bone
Simple Bone Cyst	Solitary Bone Cyst, Unspecified Site
Traumatic Bone Cyst

Amyotrophic Lateral Sclerosis 3

ALS3	Amyotrophic Lateral Sclerosis Type 3

Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

Hereditary Diffuse Leukoencephalopathy With Spheroids	Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia
Alsp	Gpsc
Subcortical Gliosis Of Neumann	Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1
Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids	Hdls
HDLS1	Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia
Gliosis, Familial Progressive Subcortical	Leukoencephalopathy, Diffuse Hereditary, With Spheroids
Pold	Pigmentary Orthochromatic Leukodystrophy
Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia	Familial Progressive Subcortical Gliosis
Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant	Dementia, Familial, Neumann Type
Adult-Onset Leukodystrophy With Neuroaxonal Spheroids	Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids
Neuroaxonal Leukodystrophy	Fpsg
Familial Dementia, Neumann Type	Familial Dementia Neumann Type
Leukoencephalopathy, Diffuse Hereditary, With Spheroid

Speech Disorder

Speech Disorders

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15309	TYROBP Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21215	Tyrobp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27731	Tyrobp Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TYROBP	VGNC	VGNC:48028
Felis catus	TYROBP	VGNC	VGNC:66740
Mus musculus	TYROBP	MGD	MGI:1277211
Rattus norvegicus	TYROBP	RGD	RGD:1303081
Bos taurus	TYROBP	VGNC	VGNC:36552

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TYROBP - transmembrane immune signaling adaptor TYROBP Gene

关于 TYROBP

功能概要

TYROBP 基因产物(4)

TYROBP 蛋白互作信息

TYROBP 抗体

关联疾病

直系同源

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TYROBP - transmembrane immune signaling adaptor TYROBP Gene

关于 TYROBP

功能概要

TYROBP 基因产物(4)

TYROBP 蛋白互作信息

TYROBP 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

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Q

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