2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. Macrophage CD Proteins Dendritic Cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. SIRP beta 1/CD172b Immunoglobulin-like Cell Adhesion Molecules
  6. Signal Regulatory Protein Beta 1
  7. SIRP beta 1 蛋白, Human (HEK293, His-Myc)

SIRP beta 1 蛋白, Human (HEK293, His-Myc)

目录号: HY-P700645
产品使用指南

SIRP beta 1 蛋白负向调节受体酪氨酸激酶信号传导并招募 SYK 来激活骨髓细胞。它作为同二聚体与 TYROBP 相互作用，促进 SYK 招募。这种复杂的分子相互作用对于调节骨髓细胞激活和细胞信号传导至关重要。SIRP beta 1 在蛋白质相互作用中占据中心位置，有助于发挥其功能作用。SIRP beta 1 蛋白, Human (HEK293, His-Myc) 是重组的 SIRP beta 1 蛋白，由 HEK293 表达，带有 N-6*His, N-Myc 标签。SIRP beta 1 蛋白, Human (HEK293, His-Myc) 全长 342 个氨基酸，分子量为 41.3 kDa。

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描述

SIRP beta 1 protein negatively regulates receptor tyrosine kinase signaling and recruits SYK for myeloid cell activation. It interacts with TYROBP as a homodimer, facilitating SYK recruitment. This intricate molecular interplay is crucial for modulating myeloid cell activation and regulating cellular signaling. SIRP beta 1 occupies a central position in protein interactions that contribute to its functional role. SIRP beta 1 Protein, Human (HEK293, His-Myc) is the recombinant human-derived SIRP beta 1 protein, expressed by HEK293 , with N-6*His, N-Myc labeled tag. The total length of SIRP beta 1 Protein, Human (HEK293, His-Myc) is 342 a.a., with molecular weight of 41.3 kDa.
研究背景

SIRP beta 1 蛋白是一种免疫球蛋白样细胞表面受体，在受体酪氨酸激酶偶联信号传导过程的负调节中发挥着至关重要的作用。此外，它还参与酪氨酸激酶 SYK 的募集，与 TYROBP 相关时触发骨髓细胞的激活。SIRP beta 1 作为具有二硫键的同二聚体存在，与 TYROBP 特异性相互作用，导致 SYK 的募集。这种复杂的分子相互作用将 SIRP beta 1 置于细胞信号传导调节的纽带，突出了其在调节骨髓细胞激活以及有助于其功能作用的复杂蛋白质相互作用网络中的重要性。
种属

Human
表达系统

HEK293
标签

N-6*His;N-Myc
蛋白编号

O00241 (E30-L371)
基因 ID
蛋白结构
N-term
6*His-Myc
SIRP beta 1 (E30-L371)
Accession # O00241
C-term
同用名
Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD172b; SIRPB1
氨基酸序列

EDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPL

分子量

41.3 kDa
纯度

Greater than 90 % as determined by SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

SIRP beta 1 Protein, Human (HEK293, His-Myc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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