2. Gene
  3. KLK11 - kallikrein related peptidase 11 Gene

KLK11 - kallikrein related peptidase 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激肽释放酶相关肽酶 11

种属: Homo sapiens

同用名: TLSP; PRSS20

基因 ID: 11012 | 基因类型: protein coding

关于 KLK11

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,022,236-51,027,991 (from NCBI)

This gene has 11 transcripts (splice variants), 171 orthologues and 12 paralogues. Biased expression in esophagus (RPKM 58.7), skin (RPKM 44.2) and 7 other tissues.

功能概要

激肽释放酶是具有不同生理功能的丝氨酸蛋白酶的一个亚组。越来越多的证据表明，许多激肽释放酶与致癌作用有关，有些具有作为新型癌症和其他疾病生物标志物的潜力。该基因是位于 19 号染色体簇中的 15 个激肽释放酶亚家族成员之一。交替剪接和交替启动子的使用导致编码差异表达的不同亚型的多个转录变体。[RefSeq 提供，2016 年 12 月]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel Cancer and Other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]

KLK11 基因产物(4)

mRNA Protein Name
NM_001136032.3 NP_001129504.1 kallikrein-11 isoform 1 precursor
NM_001167605.2 NP_001161077.1 kallikrein-11 isoform 3 precursor
NM_006853.3 NP_006844.1 kallikrein-11 isoform 1 precursor
NM_144947.3 NP_659196.1 kallikrein-11 isoform 2

KLK11 蛋白结构

Trypsin

Trypsin: Trypsin (54 - 275)

  • 0
  • 100
  • 200
  • 282 a.a.
蛋白主名 其他名称

kallikrein-11

hK11

重组 KLK11 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7381 Kallikrein-11 Protein, Human (Sf9) Q9UBX7 (E51-N282) ≥95%
HY-P70158 Kallikrein-11 Protein, Human (232a.a, HEK293, His) AAH22068 (E19-N250) ≥95%
HY-P73263 Kallikrein-11 Protein, Human (HEK293, His) Q9UBX7 (E19-N250) ≥95%

关联疾病

疾病名称 别名
Chronic Ethmoiditis

Chronic Ethmoidal Sinusitis

Chronic Ethmoid Sinusitis

Ethmoidal Sinusitis - Chronic
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07375 KLK11 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus KLK11 VGNC VGNC:67962
Mus musculus KLK11 MGD MGI:1929977
Canis familiaris KLK11 VGNC VGNC:42479
Bos taurus KLK11 VGNC VGNC:30673
Rattus norvegicus KLK11 RGD RGD:1308690
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