Kallikrein-11 蛋白, Human (Sf9)

Kallikrein 11 Protein, Human (Sf9) is a possible multifunctional protease and efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin.

激肽释放酶是丝氨酸蛋白酶的一个亚类，具有多种生理功能。越来越多的证据表明，许多激肽释放酶与致癌作用有关，其中一些有可能成为新型癌症和其他疾病的生物标志物。该基因是位于 19 号染色体簇中的 15 个激肽释放酶亚家族成员之一。该基因的交替剪接会产生两个转录变体，编码两种差异表达的不同亚型^[1]。

Specific activity determined by 100 µM colormetric peptide substrate (D-Val-Leu-Lys-ThioBenzyl ester) is >2000 pmole/min/μg.

Human

Sf9 insect cells

Tag Free

Q9UBX7 (E51-N282)

11012  [NCBI]

EFAATMLLVNQSHQGFNKEHTSKMVSAIVLYVLLAAAAHSAFAHHHHHHGSGSDDDDKETRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKPRYIVHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMKNN

Approximately 35.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS, pH 7.4.

<0.2 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. KLK11 kallikrein related peptidase 11 [ Homo sapiens (human) ]