2. Gene
  3. C5ar1 - complement component 5a receptor 1 Gene

C5ar1 - complement component 5a receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: C5aR; C5r1; Cd88; D7Msu1

基因 ID: 12273 | 基因类型: protein coding

关于 C5ar1

功能概要

Enables complement component C5a receptor activity. Involved in several processes, including astrocyte activation; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Acts upstream of or within defense response to Gram-positive bacterium; neutrophil chemotaxis; and response to peptidoglycan. Predicted to be located in several cellular components, including apical part of cell; basolateral plasma membrane; and cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; liver; neural ectoderm; and sensory organ. Orthologous to several human genes including OPRPN (opiorphin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]

C5ar1 基因产物(2)

mRNA Protein Name
NM_001173550.1 NP_001167021.1 C5a anaphylatoxin chemotactic receptor 1
NM_007577.4 NP_031603.2 C5a anaphylatoxin chemotactic receptor 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables complement component C5a receptor activity IDA
IDA: 通过直接分析推断
1401897 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta clearance IGI
IGI: 通过遗传相互作用推断
19561098 MGI
involved in astrocyte activation IGI
IGI: 通过遗传相互作用推断
19561098 MGI
involved in cognition IGI
IGI: 通过遗传相互作用推断
19561098 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
17114491 MGI
involved in microglial cell activation IGI
IGI: 通过遗传相互作用推断
19561098 MGI
acts upstream of or within neutrophil chemotaxis IMP
IMP: 通过突变表型推断
17114491 MGI
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
16452172 MGI
involved in positive regulation of macrophage chemotaxis IMP
IMP: 通过突变表型推断
16452172 MGI
involved in positive regulation of neutrophil chemotaxis IMP
IMP: 通过突变表型推断
16452172 MGI
involved in positive regulation of vascular endothelial growth factor production IMP
IMP: 通过突变表型推断
16452172 MGI
involved in presynapse organization IGI
IGI: 通过遗传相互作用推断
19561098 MGI
involved in regulation of tau-protein kinase activity IGI
IGI: 通过遗传相互作用推断
19561098 MGI
acts upstream of or within response to peptidoglycan IMP
IMP: 通过突变表型推断
17114491 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

C5a anaphylatoxin chemotactic receptor 1

C5a anaphylatoxin receptor

C5a ligand

C5a-R

complement component 5, receptor 1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-106178 PMX-53 Antagonist 99.85% Phase 2
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99450 Avdoralimab Inhibitor 99.25% Phase 2
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110136A PMX 205 Trifluoroacetate Antagonist 99.50% 否
HY-148141 JPE-1375 Antagonist 99.96% 否
HY-145237 BM213 99.81% 否
HY-P10639 C5aR2 agonist P32 Agonist 99.82% 否
HY-163378 C5aR1 antagonist 1 Antagonist / 否
HY-163379 C5aR1 antagonist 2 Antagonist / 否
HY-175981 Paclitaxel-bromothiophene / 否
HY-RS01750 C5AR1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-P10639A C5aR2 agonist P32 acetate Agonist / 否
HY-RS18377 C5ar1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24857 C5ar1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W130878 4-Octylphenol Activator / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991485 Anti-CD88/C5AR1 Antibody (G2_anti-C5aR) Inhibitor / 否
HY-P990745 Izastobart Ligand / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens C5ar1 NCBI NCBI:728
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