2. Immunology/Inflammation
  3. Complement System
  4. Avdoralimab

Avdoralimab  (Synonyms: IPH 5401; Anti-C5aR1 mAb)

目录号: HY-P99450 纯度: 95.16%
COA

摩尔计算器

Avdoralimab (IPH 5401) 是一种全人 IgGκ 单克隆抗体，靶向补体 C5a 受体 1 (C5aR1)，阻止其与 C5a 结合。Avdoralimab 可用于补体驱动的炎症性疾病和实体瘤研究。

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Avdoralimab Chemical Structure

Avdoralimab Chemical Structure

CAS No. : 2226393-85-5

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥7800
In-stock
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50 mg   询价  

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Avdoralimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Avdoralimab (IPH 5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1 (C5aR1) that prevents its binding to C5a. Avdoralimab can be used for complement-driven inflammatory diseases and solid tumours research[1].

体外研究
(In Vitro)

Avdoralimab (IPH 5401) 选择性阻断人骨髓细胞中的 C5a-C5aR1 相互作用及其下游信号传导。在体外，用 Avdoralimab (10-30 μg/mL) 阻断 C5aR1 可抑制 C5a 诱导的中性粒细胞活化。Avdoralimab 阻断由非常高浓度的 C5a 诱导的嗜中性粒细胞活化。Avdoralimab 还在体外抑制 C5a 诱导的中性粒细胞迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Avdoralimab 相关抗体:
体内研究
(In Vivo)

在敲入人类 C5aR1 的小鼠（HuC5aR1 KI 小鼠）中，Avdoralimab 阻断嗜中性粒细胞和单核细胞的浸润，阻止白蛋白在支气管肺泡灌洗液 (BALF) 中的释放，并限制 C5a 诱导的急性肺损伤 (ALI) 组织病理学特征[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

艾朵利单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Avdoralimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avdoralimab2226393-85-5IPH 5401 Anti-C5aR1 mAb艾朵利单抗IPH5401IPH-5401Complement SystemC5aR1TNF-αCCL2COVID-19inflammatory diseasessolid tumoursInhibitorinhibitorinhibit

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