CCR8 - C-C motif chemokine receptor 8 Gene

中文名称：CC 基序趋化因子受体 8

种属: Homo sapiens

同用名: CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8

基因 ID: 1237 | 基因类型: protein coding

关于 CCR8

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,329,709-39,333,680 (from NCBI)

This gene has 2 transcripts (splice variants), 236 orthologues and 23 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码β趋化因子受体家族的一员，预计是一种类似于 G 蛋白偶联受体的七次跨膜蛋白。趋化因子及其受体对于各种细胞类型迁移到炎症部位很重要。该受体蛋白优先在胸腺中表达。 I-309、胸腺激活调节细胞因子 (TARC) 和巨噬细胞炎症蛋白 1 β (MIP-1 β) 已被确定为该受体的配体。对该受体及其配体的研究表明其在调节单核细胞趋化性和胸腺细胞凋亡中的作用。更具体地说，该受体可能有助于激活的 T 细胞在抗原攻击位点和淋巴组织的特殊区域中的正确定位。该基因位于趋化因子受体基因簇区域。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the beta Chemokine Receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell Apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the Chemokine Receptor gene cluster region. [provided by RefSeq, Jul 2008]

CCR8 基因产物(1)

mRNA	Protein	Name
NM_005201.4	NP_005192.1	C-C chemokine receptor type 8

CCR8 蛋白结构

7tm_1

0
100
200
300
355 a.a.

蛋白主名

其他名称

C-C chemokine receptor type 8

CC chemokine receptor 8	CC chemokine receptor CHEMR1
CC-chemokine receptor chemr1	chemokine (C-C motif) receptor 8
chemokine (C-C) receptor 8	chemokine (C-C) receptor-like 2
chemokine receptor-like 1

重组 CCR8 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77882	CCR8 Protein-VLP, Human (HEK293)	P51685 (M1-L355)	≥95%
HY-P700400	CCR8 Protein-VLP, Human (HEK293, His)	P51685 (M1-L355)	≥95%
HY-P700542	CCR8 Protein, Human (Cell-Free, His)	P51685 (L74-V129)	≥95%
HY-P700543	CCR8 Protein, Human (P. pastoris, His)	P51685 (M1-K35)	≥95%

关联疾病

疾病名称

别名

Kaposi Sarcoma

Kaposi'S Sarcoma	Kaposi Sarcoma, Susceptibility To
Kaposi'S Sarcoma Of Lung	Kaposi'S Sarcoma Of Palate
Kaposi'S Sarcoma Of Soft Tissue	Multiple Idiopathic Pigmented Hemangiosarcoma
Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To	African Lymphadenopathic Kaposi'S Sarcoma
Anal Kaposi'S Sarcoma	Cardiac Kaposi'S Sarcoma
Central Nervous System Kaposi'S Sarcoma	Conjunctival Kaposi'S Sarcoma
Corneal Kaposi'S Sarcoma	Cutaneous Kaposi'S Sarcoma
Esophageal Kaposi'S Sarcoma	Gallbladder Kaposi'S Sarcoma
Gastric Kaposi'S Sarcoma	Intestinal Kaposi'S Sarcoma
Kaposi'S Sarcoma Of Anus	Kaposi'S Sarcoma Of Central Nervous System
Kaposi'S Sarcoma Of Conjunctiva	Kaposi'S Sarcoma Of Cornea
Kaposi'S Sarcoma Of Esophagus	Kaposi'S Sarcoma Of Gastrointestinal Sites
Kaposi'S Sarcoma Of Heart	Kaposi'S Sarcoma Of Lymph Nodes
Kaposi'S Sarcoma Of Penis	Kaposi'S Sarcoma Of Skin
Kaposi'S Sarcoma Of Soft Tissues	Kaposi'S Sarcoma Of The Cns
Kaposi'S Sarcoma Of The Gallbladder	Kaposi'S Sarcoma Of The Prostate
Kaposi'S Sarcoma, Lung	Kaposi'S Sarcoma, Skin
Kaposi'S Sarcoma-Associated Herpesvirus	Lymph Node Kaposi'S Sarcoma
Lymphadenopathic Kaposi'S Sarcoma	Palate Kaposi'S Sarcoma
Penis Kaposi'S Sarcoma	Prostate Kaposi'S Sarcoma
Pulmonary Kaposi'S Sarcoma	Soft Tissue Kaposi'S Sarcoma
Hhv8	Human Herpesvirus 8
Kshv	Kaposi Sarcoma Herpesvirus
Mediterranean Kaposi Sarcoma	Non Aids Related Kaposi Sarcoma
Sarcoma, Kaposi	Sarcoma, Kaposi, Susceptibility To
Non-Aids-Related Kaposi Sarcoma	Angiolymphoid Hyperplasia
Angiofollicular Ganglionic Hyperplasia	Multi-Centric Castleman'S Disease

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Ileitis

Crohn'S Ileitis

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101038A	ZK756326 dihydrochloride	Agonist	99.88%	否
HY-119217	AZ084	Antagonist	99.69%	否
HY-122219	R243	Antagonist	98.01%	否
HY-124416	ML604086	Inhibitor	99.80%	否
HY-121885	LMD-009	Agonist	99.76%	否
HY-144197	CCR8 antagonist 1	Antagonist	98.71%	否
HY-144200	CCR8 antagonist 2	Antagonist	99.71%	否
HY-153669	SB-649701	Antagonist	/	否
HY-160647	CCR8 antagonist 3	Antagonist	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CCR8	VGNC	VGNC:26988
Felis catus	CCR8	VGNC	VGNC:60574
Mus musculus	CCR8	MGD	MGI:1201402
Rattus norvegicus	CCR8	RGD	RGD:1304893
Macaca mulatta	CCR8	VGNC	VGNC:84216
Canis familiaris	CCR8	VGNC	VGNC:38916
Macaca fascicularis	CCR8	NCBI	NCBI:102132857
Others	CCR8	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

CCR8 - C-C motif chemokine receptor 8 Gene

关于 CCR8

功能概要

CCR8 基因产物(1)

CCR8 蛋白结构

重组 CCR8 蛋白

关联疾病

直系同源

热门区域

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CCR8 - C-C motif chemokine receptor 8 Gene

关于 CCR8

功能概要

CCR8 基因产物(1)

CCR8 蛋白结构

重组 CCR8 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z