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  2. Casr - calcium-sensing receptor Gene

Casr - calcium-sensing receptor Gene

中文名称:钙敏感受体

种属: Mus musculus

同用名: CaR; Gprc2a

基因 ID: 12374 | 基因类型: protein coding

关于 Casr

Chromosome 16: 36,314,058-36,382,503 reverse strand.GRCm39:CM001009.3

This gene has 4 transcripts (splice variants), 203 orthologues, 129 paralogues and is associated with 43 phenotypes. Biased expression in kidney adult (RPKM 6.6) and mammary gland adult (RPKM .5).

功能概要

预计该基因编码的蛋白可启动多种功能,包括整合素结合活性;蛋白质同二聚化活性;和跨膜转运蛋白结合活性。在 ATPase 活性的正调控上游或正调控内起作用;基因表达的正调控;和调节钙离子运输。预计位于多个细胞成分中,包括顶端质膜;基底外侧质膜;和神经细胞体。预计是质膜的组成部分。以多种结构表达,包括鳃袋;中枢神经系统;肺;后肾;和颈上神经节。用于研究常染色体显性低钙血症 1;家族性低尿钙性高钙血症 1;和甲状旁腺功能亢进症。该基因的人类直系同源物与多种疾病有关,包括常染色体显性低钙血症(多种);高钙血症(多发性);甲状旁腺功能亢进症(多发性);特发性全身性癫痫 8;和肾结石(多发)。与人类 CASR(钙敏感受体)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including Integrin binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Acts upstream of or within positive regulation of ATPase activity; positive regulation of gene expression; and regulation of calcium ion transport. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Predicted to be integral component of plasma membrane. Is expressed in several structures, including branchial pouch; central nervous system; lung; metanephros; and superior cervical ganglion. Used to study autosomal dominant hypocalcemia 1; familial hypocalciuric hypercalcemia 1; and hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CaSR (calcium sensing receptor). [provided by Alliance of Genome Resources, Apr 2022]

Casr 基因产物(1)

mRNA Protein Name
NM_013803.3 NP_038831.2 extracellular calcium-sensing receptor precursor

Casr 蛋白结构

PBP1_CaSR

PBP1_CaSR: cd06364 (32 - 529)

NCD3G

NCD3G: pfam07562 (537 - 590)

7tmC_CaSR

7tmC_CaSR: cd15282 (610 - 861)

7tmC_CaSR

7tmC_CaSR: cd15282 (610 - 635)

7tmC_CaSR

7tmC_CaSR: cd15282 (647 - 668)

7tmC_CaSR

7tmC_CaSR: cd15282 (677 - 701)

7tmC_CaSR

7tmC_CaSR: cd15282 (725 - 741)

7tmC_CaSR

7tmC_CaSR: cd15282 (768 - 794)

7tmC_CaSR

7tmC_CaSR: cd15282 (802 - 825)

7tmC_CaSR

7tmC_CaSR: cd15282 (830 - 855)

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  • 1079 a.a.
蛋白主名 其他名称

extracellular calcium-sensing receptor

G protein-coupled receptor, family C, group 2, member A

PCaR1

cation sensing receptor

parathyroid cell calcium-sensing receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Casr NCBI NCBI:846