1. Gene
  2. Ms4a1 - membrane-spanning 4-domains, subfamily A, member 1 Gene

Ms4a1 - membrane-spanning 4-domains, subfamily A, member 1 Gene

中文名称:跨膜 4 域,亚科 A,成员 1

种属: Mus musculus

同用名: Cd20; Ly-44; Ms4a2

基因 ID: 12482 | 基因类型: protein coding

关于 Ms4a1

Chromosome 19: 11,227,039-11,243,605 reverse strand.GRCm39:CM001012.3

This gene has 3 transcripts (splice variants), 280 orthologues, 21 paralogues and is associated with 4 phenotypes. Biased expression in spleen adult (RPKM 13.9), mammary gland adult (RPKM 3.4) and 2 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动表皮生长因子受体结合活性;相同的蛋白质结合活性;和免疫球蛋白结合活性。参与钙离子输入胞质溶胶。在对细菌的反应上游或反应内起作用。位于质膜外侧。以多种结构表达,包括消化系统;脑;淋巴系统腺体;肝脏和胆道系统;和生殖系统。该基因的人类直系同源物与常见的可变免疫缺陷有关。与人类 MS4A1 同源(膜跨越 4 个结构域 A1)。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable epidermal growth factor receptor binding activity; identical protein binding activity; and immunoglobulin binding activity. Involved in calcium ion import into cytosol. Acts upstream of or within response to bacterium. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human MS4A1 (membrane spanning 4-domains A1). [provided by Alliance of Genome Resources, Apr 2022]

Ms4a1 基因产物(1)

mRNA Protein Name
NM_007641.6 NP_031667.1 B-lymphocyte antigen CD20
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of calcium ion import across plasma membrane IDA
IDA: 通过直接分析推断
14688067 MGI
acts upstream of or within response to bacterium IEP
IEP: 通过表达模式推断
23012479 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
19723499 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ms4a1 蛋白结构

CD20

CD20: pfam04103 (43 - 209)

  • 0
  • 100
  • 200
  • 291 a.a.
蛋白主名 其他名称

B-lymphocyte antigen CD20

B-cell differentiation antigen Ly-44

CD20 antigen

lymphocyte antigen 44

membrane-spanning 4-domains, subfamily A, member 2

重组 Ms4a1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71758 CD20/MS4A1 Protein, Mouse (P.pastoris, His) P19437 (V111-P291) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ms4a1 NCBI NCBI:931
Macaca fascicularis Ms4a1 NCBI NCBI:102118491
Canis lupus familiaris Ms4a1 NCBI