1. Immunology/Inflammation
  2. CD3 CD20 Transmembrane Glycoprotein
  3. Anafiltamig

Anafiltamig 是一种靶向 CD79BCD3EMS4A1 的三价单克隆抗体抑制剂。Anafiltamig 由一条人源化 IgG1κ 抗 CD79B 臂和一条靶向 CD3E 和 MS4A1 的双特异性 scFv 臂组成。Anafiltamig 可同时桥接 T 细胞和 B 细胞,进而激活 T 细胞并特异性杀伤 B 细胞肿瘤。Anafiltamig 可用于 B 细胞恶性肿瘤(例如非霍奇金淋巴瘤)的研究。

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Anafiltamig

Anafiltamig Chemical Structure

CAS No. : 3009026-69-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anafiltamig is a trivalent monoclonal antibody inhibitor targeting CD79B, CD3E and MS4A1. Anafiltamig consists of a humanized IgG1κ anti-CD79B arm and a bispecific scFv-based arm targeting CD3E and MS4A1. Anafiltamig simultaneously bridges T and B cells, activating T cells and specifically killing B cell tumors. Anafiltamig can be used for B cell malignancies such as non-Hodgkin lymphoma research[1][2].

同型

immunoglobulin (H-gamma1_L-kappa)_(scFvkh-G1(h-CH2-CH3)-20mer-scFvkh)

反应种属

Human

IC50 & Target

CD79B & CD3E &CD20/MS4A1

基因 ID

974  [NCBI] & 916  [NCBI] & 931  [NCBI]

Accession
靶点

CD79B & CD3E &CD20/MS4A1

应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Anafiltamig
目录号:
HY-P991671
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