2. Gene
  3. Cyp1b1 - cytochrome P450, family 1, subfamily b, polypeptide 1 Gene

Cyp1b1 - cytochrome P450, family 1, subfamily b, polypeptide 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CP1B; CYPIB1; P4501b1

基因 ID: 13078 | 基因类型: protein coding

关于 Cyp1b1

功能概要

Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including camera-type eye development; cellular response to oxidative stress; and retinoid metabolic process. Acts upstream of or within several processes, including endothelial cell-cell adhesion; toxin metabolic process; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (Cytochrome P450 family 1 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp1b1 基因产物(2)

mRNA Protein Name
NM_001364889.1 NP_001351818.1 cytochrome P450 1B1 isoform 2
NM_009994.2 NP_034124.1 cytochrome P450 1B1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables monooxygenase activity IDA
IDA: 通过直接分析推断
15258110 MGI
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
IDA: 通过直接分析推断
9367523 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
19005183 MGI
involved in arachidonate metabolic process IDA
IDA: 通过直接分析推断
15258110 MGI
acts upstream of or within benzene-containing compound metabolic process IDA
IDA: 通过直接分析推断
1910294 MGI
acts upstream of or within benzene-containing compound metabolic process IMP
IMP: 通过突变表型推断
9367523 MGI
acts upstream of or within blood vessel endothelial cell migration IMP
IMP: 通过突变表型推断
19005183 MGI
involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
23568032 MGI
involved in cell adhesion IMP
IMP: 通过突变表型推断
23979599 MGI
involved in cellular response to hydrogen peroxide IMP
IMP: 通过突变表型推断
23979599 MGI
involved in collagen fibril organization IMP
IMP: 通过突变表型推断
23979599 MGI
NOT acts upstream of or within dibenzo-p-dioxin metabolic process IMP
IMP: 通过突变表型推断
16636061 MGI
involved in endothelial cell migration IMP
IMP: 通过突变表型推断
20032512 MGI
acts upstream of or within endothelial cell-cell adhesion IMP
IMP: 通过突变表型推断
19005183 MGI
involved in estrogen metabolic process IDA
IDA: 通过直接分析推断
23821647 MGI
involved in intrinsic apoptotic signaling pathway in response to oxidative stress IMP
IMP: 通过突变表型推断
23568032 MGI
involved in membrane lipid catabolic process IMP
IMP: 通过突变表型推断
19005183 MGI
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
23568032 MGI
involved in negative regulation of cell adhesion mediated by integrin IMP
IMP: 通过突变表型推断
23568032 MGI
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
23568032 MGI
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
23568032 MGI
involved in nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
20032512 MGI
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
20032512 MGI
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
23568032 MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
23568032 MGI
involved in positive regulation of vascular endothelial growth factor production IMP
IMP: 通过突变表型推断
23568032 MGI
involved in regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
19005183 MGI
acts upstream of or within response to toxic substance IMP
IMP: 通过突变表型推断
16377763 MGI
acts upstream of or within retina vasculature development in camera-type eye IMP
IMP: 通过突变表型推断
19005183 MGI
involved in retinal blood vessel morphogenesis IMP
IMP: 通过突变表型推断
20032512 MGI
involved in retinal metabolic process IDA
IDA: 通过直接分析推断
15258110 MGI
involved in retinol metabolic process IDA
IDA: 通过直接分析推断
15258110 MGI
acts upstream of or within toxin metabolic process IMP
IMP: 通过突变表型推断
10051580 MGI
involved in trabecular meshwork development IMP
IMP: 通过突变表型推断
23979599 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IMP
IMP: 通过突变表型推断
23692925 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cytochrome P450 1B1

cytochrome P450, 1b1, benz[a]anthracene inducible

cytochrome P450CMEF

cytochrome P450EF

hydroperoxy icosatetraenoate dehydratase

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1234 Octinoxate 99.84% 否
HY-W017113 2-Mercaptobenzothiazole Activator 99.85% 是
Pre-clinical Phase
生物活性分子 (29)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19340 TMS Inhibitor 99.40% 否
HY-W007700 8-Bromooctanoic acid 99.89% 否
HY-101284 DMU2105 Inhibitor 99.54% 否
HY-152118 CYP1B1-IN-4 Inhibitor 99.09% 否
HY-101285 DMU2139 Inhibitor ≥98.0% 否
HY-159006 CYP1B1 ligand 3 Inhibitor 99.83% 否
HY-146393 PROTAC CYP1B1 degrader-1 Inhibitor 98.09% 否
HY-157942 CYP1B1-IN-7 Inhibitor 99.88% 否
HY-RS03443 CYP1B1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-150557 CYP1B1-IN-1 Inhibitor / 否
HY-150558 CYP1B1-IN-2 Inhibitor / 否
HY-152079 CYP1B1-IN-3 Inhibitor / 否
HY-152196 CYP1B1-IN-5 Inhibitor / 否
HY-158429 PROTAC CYP1B1 degrader-2 Degrader / 否
HY-158430 CYP1B1 ligand 2 / 否
HY-161403 CYP1B1-IN-8 Inhibitor / 否
HY-162051 CYP1B1-IN-6 Inhibitor / 否
HY-174425 CYP1B1-IN-9 Inhibitor / 否
HY-E70476 Human CYP1B1,Low-Reductase / 否
HY-W713284 2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate / 否
HY-101284A (E/Z)-DMU2105 Inhibitor / 否
HY-126308 (E/Z)-DMU2139 Inhibitor / 否
HY-158431 (S,R,S)-AHPC-Me-8-bromooctanoic acid / 否
HY-B1234S Octinoxate-13C,d3 / 否
HY-RS16945 Cyp1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23388 Cyp1b1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W472509 11-HETE Activator / 否
HY-W517092 1,2,3,4,7,8,9-Heptachlorodibenzofuran / 否
HY-W775354 1,2,3,4,7,8-Hexachlorodibenzofuran / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cyp1b1 NCBI NCBI:1545
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