2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP1B1-IN-11

CYP1B1-IN-11 (Compound M2) 是一种选择性 CYP1B1 抑制剂，IC50 为 0.00605 pM。CYP1B1-IN-11 可有效逆转DMBA (HY-W011845) 诱导的 Paclitaxel (HY-B0015) 耐药性，并抑制肿瘤细胞的侵袭和迁移。CYP1B1-IN-11 可用于肿瘤耐药性研究。

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CYP1B1-IN-11

CYP1B1-IN-11 Chemical Structure

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CYP1B1-IN-11 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYP1B1-IN-11 (Compound M2) is a selective CYP1B1 inhibitor with an IC50 of 0.00605 pM. CYP1B1-IN-11 effectively reverses DMBA (HY-W011845)-induced Paclitaxel (HY-B0015) resistance and CYP1B1-IN-11 suppresses tumor cells invasion and migration. CYP1B1-IN-11 can be used for tumor drug resistance research[1].

IC50 & Target[1]

CYP1B1

0.00605 pM (IC50)

CYP1A2

1615 nM (IC50)

CYP1A1

8.3 nM (IC50)

分子量

345.80

Formula

C18H17ClFN3O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CYP1B1-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP1B1-IN-11Cytochrome P450CYPsCYP1B1DMBAPaclitaxelA549 cellsTumorDrug resistanceInhibitorinhibitorinhibit

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