2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP1B1-IN-3

CYP1B1-IN-3 是一种有效的选择性 CYP1B1 抑制剂，对 CYP1B1、CYP1A1、CYP1A2 的 IC50 值分别为6.6, 347.3, >10000 nM。CYP1B1-IN-3 抑制细胞迁移和侵袭。CYP1B1-IN-3 抑制 P-gp、AKT/ERK、FAK/SRC 和 EMT 通路。

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CYP1B1-IN-3 Chemical Structure

CYP1B1-IN-3 Chemical Structure

CAS No. : 2872575-51-2

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CYP1B1-IN-3 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways[1].

IC50 & Target[1]

CYP1B1

6.6 nM (IC50)

CYP1A1

347.3 nM (IC50)

CYP1A2

>10000 nM (IC50)

体外研究
(In Vitro)

CYP1B1-IN-3 (compound 77) (3.75-30.0 μM; 72 h) 增加 A549/Taxol 细胞对Taxol (0.06-1 μM) 的敏感性[1]。
CYP1B1-IN-3 (2.5, 5, 10 µM) 抑制 A549 细胞和 A549/Taxol 细胞的迁移和侵袭[1]。
CYP1B1-IN-3 (2.5, 5, 10 µM; 24 h) 抑制 A549/Taxol 细胞中的 AKT/ERK、FAK/SRC 和 EMT 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CYP1B1-IN-3 相关抗体:

Western Blot Analysis[1]

Cell Line: A549/Taxol cells
Concentration: 2.5, 5, 10 µM
Incubation Time: 24 h
Result: Decreased the expression of P-gp, p-AKT, AKT, p-ERK1/2 (T202/Y204), ERK1/2, p-FAK (Y576), FAK, p-SRC in a dose-dependent manner.
分子量

413.49

Formula

C20H16FN3O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CYP1B1-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP1B1-IN-32872575-51-2Cytochrome P450CYPsInhibitorinhibitorinhibit

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