2. Gene
  3. Gdf11 - growth differentiation factor 11 Gene

Gdf11 - growth differentiation factor 11 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Bmp11; BMP-11

基因 ID: 14561 | 基因类型: protein coding

关于 Gdf11

功能概要

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and Other organ systems, and may regulate aging. Mice lacking a functional copy of this gene exhibit impaired anteroposterior patterning and Other developmental defects. [provided by RefSeq, Aug 2016]

Gdf11 基因产物(1)

mRNA Protein Name
NM_010272.2 NP_034402.1 growth/differentiation factor 11 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16845371 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of amacrine cell differentiation IDA
IDA: 通过直接分析推断
15976303 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
15548585 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
10391213 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: 通过突变表型推断
15976303 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
15548585 MGI
acts upstream of or within metanephros development IDA
IDA: 通过直接分析推断
12729564 MGI
acts upstream of or within negative regulation of amacrine cell differentiation IDA
IDA: 通过直接分析推断
15976303 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15548585 MGI
acts upstream of or within negative regulation of neuron differentiation IDA
IDA: 通过直接分析推断
15976303 MGI
acts upstream of neuron differentiation IDA
IDA: 通过直接分析推断
15976303 MGI
acts upstream of or within pancreas development IMP
IMP: 通过突变表型推断
15548585 MGI
involved in positive regulation of SMAD protein signal transduction IDA
IDA: 通过直接分析推断
16845371 MGI
acts upstream of or within roof of mouth development IGI
IGI: 通过遗传相互作用推断
24019467 MGI
acts upstream of or within skeletal system development IGI
IGI: 通过遗传相互作用推断
24019467 MGI
acts upstream of or within spinal cord anterior/posterior patterning IMP
IMP: 通过突变表型推断
16790475 MGI
acts upstream of or within type B pancreatic cell maturation IMP
IMP: 通过突变表型推断
15548585 MGI
acts upstream of or within ureteric bud development IMP
IMP: 通过突变表型推断
12729564 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
12729564 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

growth/differentiation factor 11

GDF-11

bone morphogenetic protein 11

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99720 Luspatercept Inhibitor 98.92% 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05351 GDF11 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18279 Gdf11 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24757 Gdf11 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990733 Cibotercept Inhibitor 99.85% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gdf11 NCBI NCBI:10220
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